Publications by authors named "Ya-li Zhang"

L. (POL) has a long history of medicinal use worldwide, and numerous clinical and experimental studies demonstrated the therapeutic effects of POL and its active ingredients in the treatment of Ulcerative colitis (UC). In this review, we summarized the underlying mechanisms and roles of POL in UC treatment based on experimental and clinical studies.

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  • Abdominal pain is a key symptom of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, greatly affecting patients' quality of life.
  • The review analyzes recent research over the last decade regarding the epidemiology, pathophysiology, and management strategies for abdominal pain in IBD.
  • It highlights emerging trends, challenges, and advancements in understanding how abdominal pain relates to disease progression and treatment options for IBD patients.
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Herein, a label-free single-molecule electrical sensor was first proposed for the ultrasensitive and selective detection of iodide ions in human urine. Single-molecule conductance measurements in different halogen ion solutions via scanning tunneling microscopy break junction (STM-BJ) clearly revealed that I ions strongly affect the stability and displacement distance (Δ) distribution of molecular junctions. Theoretical calculations prove that the specific adsorption of I ions modifies the surface properties and weakens the molecular adsorption.

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This study aimed to determine the expression levels of the autophagy markers Beclin-1 and p62 in patients with diffuse large B-cell lymphoma (DLBCL) and explore the association between autophagy and disease prognosis. The expression of Beclin-1 and p62 was investigated in patients with DLBCL and patients with reactive lymphoproliferative disease (RLD) using immunohistochemistry. The association between the clinical characteristics of patients with DLBCL and autophagy status was further analyzed.

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Objective: To understand the etiology, clinical characteristics and prognosis of secondary hemophagocytic syndrome (HLH), so as to improve the understanding of HLH and reduce the rates of misdiagnosis and missed diagnosis of HLH.

Methods: A retrospective study was conducted to analyze the cause, clinical characteristics, laboratory findings, therapy and outcomes of 75 adult patients with secondary HLH admitted to our hospital from January 2015 to December 2021. Follow-up continued until the last discharge time.

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Ethnopharmacological Relevance: Hyssopus cuspidatus Boriss., a classic Uyghur medicine, is used to treat inflammatory lung diseases such as asthma. But the therapeutic effect and mechanism of the volatile oil of Hyssopus cuspidatus Boriss.

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Background: Both N6-methyladenosine (m6A) methylation and autophagy are considered relevant to the pathogenesis of ulcerative colitis (UC). However, a systematic exploration of the role of the com-bination of m6A methylation and autophagy in UC remains to be performed.

Aim: To elucidate the autophagy-related genes of m6A with a diagnostic value for UC.

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  • Viral encephalitis is a serious illness caused by different viruses, making it hard to diagnose around the world.
  • Researchers developed a new way to detect these viruses using a special technology that can quickly analyze many samples at once.
  • Their tests showed that this new method works well and produces reliable results, so it can help doctors identify the illness better.
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Ethnopharmacological Relevance: Scrophulariae Radix (Xuanshen [XS]) has been used for several years to treat hyperthyroidism. However, its effective substances and pharmacological mechanisms in the treatment of hyperthyroidism and thyroid hormone-induced liver and kidney injuries have not yet been elucidated.

Aim Of The Study: This study aimed to explore the pharmacological material basis and potential mechanism of XS therapy for hyperthyroidism and thyroid hormone-induced liver and kidney injuries based on network pharmacology prediction and experimental validation.

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Objective: To explore the correlation between gene mutations and clinical characteristics, prognosis of myelodysplastic syndromes (MDS).

Methods: Clinical data of 131 patients with MDS were collected from the First Hospital of Lanzhou University from June 2015 to February 2023, which 19 of them developed into secondary acute myeloid leukemia (sAML) during follow-up time. Second generation sequencing technology was used to detect the mutation types of MDS disease-related genes, drawn gene maps, and analyzed their correlation and prognosis based on the clinical data of patients.

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Objectives: Lymphocyte subsets are the predictors of disease diagnosis, treatment, and prognosis. Determination of lymphocyte subsets is usually carried out by flow cytometry. Despite recent advances in flow cytometry analysis, most flow cytometry data can be challenging with manual gating, which is labor-intensive, time-consuming, and error-prone.

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Rationale And Objectives: Traditional Ki-67 evaluation in breast cancer (BC) via core needle biopsy is limited by repeatability and heterogeneity. The automated breast ultrasound system (ABUS) offers reproducibility but is constrained to morphological and echoic assessments. Radiomics and machine learning (ML) offer solutions, but their integration for improving Ki-67 predictive accuracy in BC remains unexplored.

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Apple epidermal wax protects plants from environmental stresses, determines fruit gloss and improves postharvest storage quality. However, the molecular mechanisms underlying the biosynthesis and regulation of apple epidermal waxes are not fully understood. In this study, we isolated a MdDEWAX gene from apple, which localized in the nucleus, expressed mainly in apple fruit, and induced by drought.

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Traditional Chinese medicine (TCM) is widely used in clinical practice, including skin and gastrointestinal diseases. Here, a potential TCM QY305 (T-QY305) is reported that can modulate the recruitment of neutrophil in skin and colon tissue thus reducing cutaneous adverse reaction and diarrhea induced by epidermal growth factor receptor inhibitors (EGFRIs). On another hand, the T-QY305 formula, through regulating neutrophil recruitment features would highlight the presence of N-QY305, a subunit nanostructure contained in T-QY305, and confirm its role as potentially being the biomaterial conferring to T-QY305 its pharmacodynamic features.

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  • * Twelve new types of pore-space-partitioned MOFs (pacs-MOFs) were created, featuring various functional groups like electron-donors (-OH, -NH) and electron-acceptors (-NO, -F), which influence CO behavior.
  • * Results indicated that MOFs with electron-donating groups, especially SNNU-25-OH, showed superior CO adsorption and catalytic activity due to favorable interactions with CO molecules, aiding future designs for efficient CO utilization.
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Exploring moisture distribution, especially bound water content, is vital for studying and applying sludge dewatering. The differential scanning calorimetry (DSC) method has been extensively utilized for the quantitative characterization of moisture distribution in sludge. However, this method has certain limitations, such as low reproducibility of results, leading to controversial parameter values in different papers and hindering result comparison.

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With its long clinical history, traditional Chinese medicine (TCM) has gained acceptance for its specific efficacy and safety in the treatment of multiple diseases. Nano-sized materials study of Chinese herbal medicines (CHMs) leads to an increased understanding of assessing TCM therapies, which may be a promising way to illustrate the material basis of CHMs through their processing and extraction. In this review, we provide an overview of the nanostructures of natural and engineered CHMs, including extracted CHMs, polymer nanoparticles, liposomes, micelles, and nanofibers.

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To explore the changes and the reaction mechanisms between soil microecological environment and the content of secon-dary metabolites of plants under water deficit, this study carried out a pot experiment on the 3-leaf stage seedlings of Rheum officinale to analyze their response mechanism under different drought gradients(normal water supply, mild, moderate, and severe drought). The results indicated that the content of flavonoids, phenols, terpenoids, and alkaloids in the root of R. officinale varied greatly under drought stresses.

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Background: Colorectal cancer (CRC) is the third most common cancer worldwide, with the fourth highest mortality among all cancers. Reportedly, in addition to adenomas, serrated polyps, which account for 15%-30% of CRCs, can also develop into CRCs through the serrated pathway. Sessile serrated adenomas/polyps (SSAs/Ps), a type of serrated polyps, are easily misdiagnosed during endoscopy.

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  • * It evaluates the impact of parameters like standard curves, scanning times, and sample weight on the accuracy of the low-field nuclear magnetic resonance (LF-NMR) method for measuring sludge water content.
  • * Findings reveal that magnetic substances in sludge can distort LF-NMR results, with a strong correlation between saturation magnetization and measurement errors, highlighting the need for tailored process considerations rather than relying on standard literature methods.
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Although livestock manure serves as an effective source of nutrients for agricultural purposes, it also causes an obvious risk of contamination of heavy metals and pathogens in soil. Soil microorganisms are always considered a sensitive indicator for the change in soil quality. However, knowledge of the effects of cow manure application on soil microbial community is still scarce.

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A key function of SUMOylation is the coordinated modification of numerous proteins to optimize plant growth and resistance to environmental stress. Plant cuticular wax is deposited on the surface of primary plant organs to form a barrier that provides protection against changes in terrestrial environments. Many recent studies have examined cuticular wax biosynthetic pathways and regulation.

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  • Xiaokeyinshui extract combination (XEC) is derived from an ancient Chinese formula and has been shown to lower blood sugar levels, but its chemical composition and how it behaves in the body were not well understood.
  • Researchers developed advanced methods to identify and study the chemical components of XEC in rats, which led to the discovery of 58 compounds and numerous metabolites, revealing various metabolic processes influencing these substances.
  • Seven specific compounds, including berberine and palmatine, were identified for comparative studies between normal and diabetic rats, showing significant differences in how these ingredients were processed in diabetic versus non-diabetic conditions.
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  • Ulcerative colitis (UC) is a complex condition influenced by genetic and environmental factors that disrupt immune responses, and researchers are using single-cell RNA sequencing (scRNA-seq) to better understand its biological underpinnings.
  • The study aims to identify clinical phenotypes and biomarkers in UC patients to predict their responses to specific therapies, enhancing diagnosis and treatment strategies.
  • By analyzing a large dataset of immune cells through various gene analysis methods, researchers found three core genes—RhoB, cathepsin D, and zyxin—that are strongly linked to immune responses and may improve understanding and management of UC.
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