CircSmg5 stimulates the osteogenic differentiation of bone marrow mesenchymal stem cells by targeting the miR-194-5p/Fzd6 axis and beta-catenin signaling.

Background: Osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is closely associated with bone diseases. Circular RNAs are reported to be involved in BMSC differentiation. CircSmg5 (circ_0001145) has been identified to be downregulated in an osteoporosis mouse model.

Bone Material Properties of Human Phalanges Using Vickers Indentation.

Objective: To investigate the microhardness distribution throughout the human hand phalanges using the Vickers method, which can be used to directly evaluate the bone mechanical properties at tissue level and provide an alternative means to investigate bone quality.

Methods: The phalanges bones involved in this study were collected from three healthy donors; fresh-frozen right limbs were used. The phalanges bones were dissected and cut into 3-mm thick slices perpendicular to the long axis in the phalanges base, the phalanges shaft, and the phalanges head with a low-speed saw and then the slices were polished with sandpaper.

Profiling lncRNA alterations during TNF‑α induced osteogenic differentiation of dental pulp stem cells.

The multipotent and easily accessible characteristics of dental pulp stem cells (DPSCs) make them a promising target for bone tissue engineering. Long non‑coding RNAs (lncRNAs) have an important role in the osteogenic differentiation of mesenchymal stem cells. Nevertheless, whether lncRNAs are involved in the osteogenic differentiation of DPSCs remains unclear.

A prospective comparative study of hip resurfacing arthroplasty and large-diameter head metal-on-metal total hip arthroplasty in younger patients-a minimum of five year follow-up.

Introduction: Both hip resurfacing arthroplasty (HRA) and large-diameter head metal-on-metal total hip arthroplasty (LDH MoM THA) are generally used for young and active patients. A number of comparative studies of HRA and total hip arthroplasty have been published in the literature. However, studies that have compared HRA with LDH MoM THA are rare.

N-acetylcysteine Attenuates Cobalt Nanoparticle-Induced Cytotoxic Effects through Inhibition of Cell Death, Reactive Oxygen Species-related Signaling and Cytokines Expression.

Objective: Complex cobalt-chromium alloys, bearing surfaces of the second-generation metal-on-metal (MoM) hip prostheses, are subject to wear and generate cobalt nanoparticles (CoNPs). CoNPs could reduce cellular viability, activate the mitogen-activated protein kinase (MAPK) pathway and increase cell apoptosis via reactive oxygen species (ROS). However, the detailed mechanisms of ROS functioning on CoNP-mediated signaling molecules and cytotoxicity has not yet been fully demonstrated.

Transcriptome changes during TNF-α promoted osteogenic differentiation of dental pulp stem cells (DPSCs).

Dental pulp stem cells (DPSCs), due to the ease of isolation and their capacities of multi-lineage differentiation, are considered as attractive resources for regenerative medicine. In a previous study, we showed that TNF-α promoted the osteogenic differentiation of DPSCs via the NF-κB signaling pathway. However, the mechanisms of such differentiation were largely unknown.

Prevention of Surgical Site Infection After Ankle Surgery Using Vacuum-Assisted Closure Therapy in High-Risk Patients With Diabetes.

Patients with diabetes have a high risk of surgical site infection (SSI) after ankle surgery. The aim of the present study was to investigate the efficacy of vacuum-assisted closure (VAC) in the prevention of SSI after ankle surgery compared with the efficacy of standard moist wound care (SMWC). A retrospective study was performed of unstable ankle fractures for surgical fixation in patients with diabetes from January 2012 to December 2014.

Gender differences of venous thromboembolism risk after total hip and total knee arthroplasty: a meta-analysis.

We performed a meta-analysis to evaluate gender differences of venous thromboembolism (VTE) risk after total hip (THA) and total knee arthroplasty (TKA). We searched PubMed and Web of Knowledge from their beginning to 25 July 2015. Pooled odds ratio (OR) and 95 % confidence interval (CI) for VTE risk were calculated.

HbA1c and Lower Extremity Amputation Risk in Patients With Diabetes: A Meta-Analysis.

In this meta-analysis, we aimed to assess glycosylated hemoglobin (HbA1c) level and lower extremity amputation (LEA) risk in patients with diabetes. Systematic computerized searches of the PubMed and Web of Knowledge were performed. We compared HbA1c level between groups with LEA and without LEA by meta-analysis; we also examined the dose-response relationship between HbA1c level and LEA risk.

Wound management with vacuum assisted closure in surgical site infection after ankle surgery.

Objective: The aim of this study was to compare the efficacy of vacuum assisted closure (VAC) with standard moist wound care (SMWC) in surgical site infection after ankle surgery.

Methods: A prospective cohort was performed among patients with surgical site infection after ankle surgery between 2012 and 2013. The follow-up period was three month, and the efficacy end point was complete wound closure rate.

Body mass index and knee osteoarthritis risk: a dose-response meta-analysis.

Objective: Evidence shows obesity is an important risk factor for knee osteoarthritis (OA). However, the dose-response relationship between body mass index (BMI) and knee OA risk is unclear. The purpose of the current study is to establish a nonlinear dose-response relationship between BMI and risk of knee OA.

Effects of serum cobalt ion concentration on the liver, kidney and heart in mice.

Objective: To investigate the effects of serum cobalt ion concentration on the liver, kidney and heart in mice.

Methods: Forty 4-week-old male ICR mice were randomly divided into four groups (n = 10 in each group) as follows: Group 1 (HD), high-dose cobalt chloride group (3.28 mg/kg/day); Group 2 (MD), medium-dose cobalt chloride group (1.

[Treatment of type C intercondylar fractures of distal humerus using dual plating].

Objective: To evaluate the clinical outcome of dual plating in the treatment of humeral intercondylar type-C fractures in adults.

Methods: From June 2004 to October 2007, 38 cases of type-C distal humeral fractures were stabilised with dual plating. There were 21 males and 17 females.