Research Progress on Sesquiterpenes from the Genus .

Sesquiterpenes constitute the principal components of the genus , encompassing guaiane, germacrane, eudesmane, and polymer sesquiterpene lactones types. These secondary metabolites exhibit diverse pharmacological activities, including antitumor, antibacterial, anti-inflammatory, antiviral, antioxidant, hepatoprotective, and neuroprotective effects. Through a comprehensive literature search of the Web of Science, PubMed, SciFinder, and CNKI databases, it was discovered that there are as many as 145 main sesquiterpenoids in the genus .

Heavy metals in sediments of the river-lake system in the Dianchi basin, China: Their pollution, sources, and risks.

The accumulation of heavy metals in river and lake sediments in basins seriously threatens ecological safety and human health. To manage the basin effectively, it is crucial to understand pollution levels and identify and quantify the sources and risks of heavy metals in rivers and lakes separately for targeted control. In this study, 34 sediment samples were collected from the Dianchi Basin, China, and the pollution, sources, and risks in the river-lake system sediments were systematically analysed for cadmium (Cd), chromium (Cr), arsenic (As), mercury (Hg), lead (Pb), copper (Cu), zinc (Zn), and nickel (Ni).

Transcutaneous auricular vagal nerve stimulation for consciousness recovery in patients with prolonged disorders of consciousness (TAVREC): study protocol for a multicenter, triple-blind, randomized controlled trial in China.

Introduction: Prolonged disorders of consciousness (pDoC) are a catastrophic condition following brain injury with few therapeutic options. Transcutaneous auricular vagal nerve stimulation (taVNS), a safe, non-invasive intervention modulating thalamo-cortical connectivity and brain function, is a possible treatment option of pDoC. We developed a protocol for a randomised controlled study to evaluate the effectiveness of taVNS on consciousness recovery in patients with pDoC (TAVREC).

Brevilin A ameliorates sepsis-induced cardiomyopathy through inhibiting NLRP3 inflammation.

Background: Sepsis is a systemic inflammatory disease, and Brevilin A (BA) has a powerful anti-inflammatory effect. However, whether BA has a similar effect on septic cardiomyopathy remains unclear. This study aimed to investigate the effect and mechanism of BA in septic cardiomyopathy.

Promising way to address massive intragastric clotting in patients with acute upper gastrointestinal bleeding: A case report.

Background: Massive intragastric clotting (MIC) makes endoscopic therapy difficult in patients with acute upper gastrointestinal bleeding. Literature data on how to address this problem are limited. Here, we report on a case of massive stomach bleeding with MIC that was successfully treated endoscopically using an overtube of single-balloon enteroscopy.

IL-18-Mediated SLC7A5 Overexpression Enhances Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells the c-MYC Pathway.

To investigate the role of IL-18 in the regulation of osteogenic differentiation in human bone marrow mesenchymal stem cells (hBMSCs). To assess whether IL-18 affects the osteogenic differentiation of hBMSCs through the c-MYC/SLC7A5 axis, IL-18 dose-response and time-course experiments were performed to evaluate its impact on osteogenic differentiation. To confirm osteogenic differentiation, alizarin red staining calcium measurement were performed.

Bioinspired Color-Changeable Organogel Tactile Sensor with Excellent Overall Performance.

Inspired by chameleons' structural color regulation capability, a simple, but effective, swelling method is proposed for the first time to prepare an ionic polyacrylamide (PAAm) organogel for simultaneous tactile sensing and interactive color changing. The PAAm organogel obtained by swelling the PAAm scaffold in the dimethyl sulfoxide solution of organic electrochromic material (OECM) shows an extremely large stretchability with an elongation of 1600%, a supersoftness with a compressive modulus of 7.2 kPa, an excellent transmittance up to 90%, and a very fast response time of 0.

Spider-Inspired Ultrasensitive Flexible Vibration Sensor for Multifunctional Sensing.

Flexible vibration sensors can not only capture broad classes of physiologically relevant information, including mechano-vibration signatures of body processes and precision kinematics of core-body motions, but also detect environmental seismic waves, providing early warning to wearers in time. Spider is one of the most vibration-sensitive creatures because of its hairlike sensilla and lyriform slit structure. Here, a spider-inspired ultrasensitive flexible vibration sensor is designed and fabricated for multifunctional sensing.

Prognostic Value Of The Preoperative Neutrophil To Lymphocyte Ratio In Patients With Sinonasal Squamous Cell Carcinoma.

Objective: This study explored the effectiveness of a new inflammatory prognostic system, using preoperative neutrophil to lymphocyte ratio (NLR) to predict the postoperative survival rate of patients with sinonasal squamous cell carcinoma (SSCC).

Methods: Patients diagnosed with SSCC who undergone surgically treated without neoadjuvant therapy were included in the study between May 2008 and October 2017. Preoperative NLR is defined as: preoperative neutrophil/postoperative lymphocyte ratio.

Correction: May the change of platelet to lymphocyte ratio be a prognostic factor for T3-T4 laryngeal squamous cell carcinoma: A retrospective study.

[This corrects the article DOI: 10.1371/journal.pone.

Intraoperative Repair of Cerebrospinal Fluid Rhinorrhea in Skull Base Tumor Resection: A Retrospective Study of Acellular Dermal Matrix Versus Turbinate Flap.

Background: The acellular dermal matrix (ADM) and turbinate flap (TF) have been widely used in the reconstruction of skull base defects. However, owing to the lack of reported data, the therapeutic effects have been controversial. The purpose of the present study was to compare the effect of the ADM and TF on cerebrospinal fluid (CSF) rhinorrhea after nasal endoscopic resection of a skull base tumor.

Effect of High-Intensity Focused Ultrasound Versus Plasma Radiofrequency Ablation on Recurrent Allergic Rhinitis.

BACKGROUND High-intensity focused ultrasound (HIFU) and plasma radiofrequency ablation (PRA) have been used to treat recurrent allergic rhinitis (AR); however, there is a lack of literature comparing the efficacy of these 2 methods. We assessed and compared the therapeutic effects of HIFU and PRA on recurrent AR. MATERIAL AND METHODS We enrolled 66 patients with recurrent AR at West China Hospital of Sichuan University.

Risk factors for lower respiratory tract infection in children with tracheobronchial foreign body aspiration.

The aim of this study was to determine the risk factors for lower respiratory tract infection (LRTI) in children caused by tracheobronchial foreign body aspiration (TFBA).A total of 351 patients were retrospectively reviewed; all patients were diagnosed with TFBA at West China Hospital of Sichuan University from 2015 to 2017. Univariate analyses and multivariate analysis were used.

Acellular dermal matrix contributes to epithelialization in patients with chronic sinusitis.

Background: Nasal endoscopic surgery is widely used for nasal diseases, including sinusitis and tumors. However, scar hyperplasia, nasal irritation, scab, and nasal obstruction delay nasal mucosal recovery, with prolonged cleaning exacerbating the patient's financial burden. Here, we presented a novel approach for the treatment of nasal mucosal defects, termed acellular dermal matrix.

May the change of platelet to lymphocyte ratio be a prognostic factor for T3-T4 laryngeal squamous cell carcinoma: A retrospective study.

Background: Many blood markers have been shown to predict the recurrence and survival of various malignancies, but the effects of surgery on the body's inflammatory levels may cause changes in these inflammatory markers. Therefore, in this study, we assessed the relationship between changes in platelet to lymphocyte ratio (PLR) and survival and recurrence in patients with T3-T4 laryngeal squamous cell carcinoma (LSCC).

Methods: Data of patients with T3-T4 HSCC were reviewed.

LLE Score: A New Filter-Based Unsupervised Feature Selection Method Based on Nonlinear Manifold Embedding and Its Application to Image Recognition.

The task of feature selection is to find the most representative features from the original high-dimensional data. Because of the absence of the information of class labels, selecting the appropriate features in unsupervised learning scenarios is much harder than that in supervised scenarios. In this paper, we investigate the potential of locally linear embedding (LLE), which is a popular manifold learning method, in feature selection task.

Automated, highly reproducible, wide-field, light-based cortical mapping method using a commercial stereo microscope and its applications.

We introduce a more flexible optogenetics-based mapping system attached on a stereo microscope, which offers automatic light stimulation to individual regions of interest in the cortex that expresses light-activated channelrhodopsin-2 . Combining simultaneous recording of electromyography from specific forelimb muscles, we demonstrate that this system offers much better efficiency and precision in mapping distinct domains for controlling limb muscles in the mouse motor cortex. Furthermore, the compact and modular design of the system also yields a simple and flexible implementation to different commercial stereo microscopes, and thus could be widely used among laboratories.