Neuropeptide-mediated activation of astrocytes improves stress resilience in mice by modulating cortical neural synapses.

Astrocytes are known to modulate synaptogenesis or neuronal activities, thus participating in mental functions. It has been shown that astrocytes are involved in the antidepressant mechanism. In this study we investigated the potential hormonal mediator governing the astrocyte-neuron interplay for stress-coping behaviors.

Clinical characteristics and long-term outcomes for parapharyngeal metastases of well-differentiated thyroid cancer during I therapy and follow-up.

Objective: Parapharyngeal metastases (PPM) are rarely observed in patients with well-differentiated thyroid cancer (WDTC). Radioiodine ( I) therapy has been the main treatment for metastatic and recurrent DTC after thyroidectomy. This study was performed to evaluate the clinicopathological features and long-term outcomes associated with survival of patients with PPM at the end of follow-up.

[Litter decomposition and its effects on soil microbial community in Shapotou area, China].

We investigated the decomposition characteristics of , mosses, and leaves of with litterbag method in the sand-binding revegetation area, southeastern edge of the Tengger Desert, and further examined their effects on soil microbial communities using the Illumina MiSeq sequencing method. The results showed that the decomposition duration and litter types significantly affected litter decomposition rate. Mosses had the lowest decomposition rate, with a mass loss ratio of only 15.

Correction: Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice.

[This corrects the article DOI: 10.18632/oncotarget.17638.

Screening for Susceptibility-Related Factors and Biomarkers of Xianling Gubao Capsule-Induced Liver Injury.

Although increasing reports from the literature on herbal-related hepatotoxicity, the identification of susceptibility-related factors and biomarkers remains challenging due to idiosyncratic drug-induced liver injury (IDILI). As a well-known Chinese medicine prescription, Xianling Gubao Capsule (XLGB) has attracted great attention due to reports of potential liver toxicity. But the mechanism behind it is difficult to determine.

[Analysis on adolescent depression treated with acupuncture based on the theory of "taking as the pivot"].

Depression is related to stagnation in the body. At present, the treatment with acupuncture for depression focuses on the theories of the governor vessel, liver, spleen, stomach and the entity of five organs, especially for the adult group. However, the attention to adolescent depression is insufficient.

The MAPK Kinase Kinase GmMEKK1 Regulates Cell Death and Defense Responses.

MAPK signaling pathways play critical roles in plant immunity. Here, we silenced multiple genes encoding MAPKs using virus-induced gene silencing mediated by to identify MAPK genes involved in soybean () immunity. Surprisingly, a strong hypersensitive response (HR) cell death was observed when soybean (), a homolog of Arabidopsis () , was silenced.

Discovering Associations of Adverse Events with Pharmacotherapy in Patients with Non-Small Cell Lung Cancer Using Modified Apriori Algorithm.

Aim: To explore the associations between adverse events and pharmacotherapy in patients with non-small cell lung cancer.

Methods: 16,527 patients with non-small cell lung cancer admitted to the Cancer Hospital, Chinese Academy of Medical Sciences, between January 1, 2010, and December 31, 2016, were included in the study. Their medication and laboratory examinations data were extracted from the medical records.

Excessive Cellular -nitrosothiol Impairs Endocytosis of Auxin Efflux Transporter PIN2.

-nitrosoglutathione reductase (GSNOR1) is the key enzyme that regulates cellular levels of -nitrosylation across kingdoms. We have previously reported that loss of GSNOR1 resulted in impaired auxin signaling and compromised auxin transport in Arabidopsis, leading to the auxin-related morphological phenotypes. However, the molecular mechanism underpinning the compromised auxin transport in mutant is still unknown.

Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice.

The Chinese formula Bushen-Yizhi (BSYZ) has been reported to ameliorate cognitive dysfunction. However the mechanism is still unclear. In this study, we employ an aging model, SAMP8 mice, to explore whether BSYZ could protect dementia through SIRT1/endoplasmic reticulum (ER) stress pathway.

[Species composition and population structure of plant communities on semi-fixed dunes of the Gurbantongut Desert, China.].

The objective of this study was to investigate species composition, and predict future development of dominant species on semi-fixed sand dunes in the Gurbantongut Desert. Using the plant height, crown area and volume instead of age structure, the growth and development condition of dominant shrub populations were analyzed. The results showed that totally 23 species were observed, of which Chenopodiaceae occurred the most with 6 genera 8 species, followed by Asteraceae with 5 genera 6 species.

[Differentiation Study of Chinese Medical Syndrome Typing for Diarrhea-predominant Irritable Bowel Syndrome Based on Information of Four Chinese Medical Diagnostic Methods and Brain-gut Peptides].

Objective: To establish discriminant functions of diarrhea-predominant irritable bowel syndrome (IBS-D) by studying it from quantitative diagnosis angle, hoping to reduce interference of subjective factors in diagnosing and differentially diagnosing Chinese medical syndromes of IBS-D.

Methods: A Chinese medical clinical epidemiological survey was carried out in 439 IBS-D patients using Clinical Information Collection Table of IBS. Initial syndromes were obtained by cluster analysis.

Loss of GSNOR1 Function Leads to Compromised Auxin Signaling and Polar Auxin Transport.

Cross talk between phytohormones, nitric oxide (NO), and auxin has been implicated in the control of plant growth and development. Two recent reports indicate that NO promoted auxin signaling but inhibited auxin transport probably through S-nitrosylation. However, genetic evidence for the effect of S-nitrosylation on auxin physiology has been lacking.

Clinical Research on Brain Natriuretic Peptide Guiding the Application of β1 Receptor Blocker in Patients with Moderate to Severe Heart Failure.

Background: This study aimed to explore the feasibility of guiding the application of metoprolol succinate in patients with moderate to severe heart failure (HF) through monitoring plasma brain natriuretic peptide (BNP) levels.

Methods: A total of 195 patients with moderate to severe HF (NYHA Functional Class III to IV) were selected and randomized into two groups: an observation group and a BNP group. The groups were established to observe the clinical conditions and establish plasma BNP levels to guide the application of metoprolol succinate.

The stability of aerobic granular sludge treating municipal sludge deep dewatering filtrate in a bench scale sequencing batch reactor.

Inoculated with mature aerobic granular sludge in a sequencing batch reactor, gradually increasing the proportion of municipal sludge deep dewatering filtrate in influent, aerobic granular sludge was domesticated after 84 days and maintained its structure during the operation. The domesticated AGS was yellowish-brown, dense and irregular spherical shape, average size was 1.49 mm, water content and specific density were 98.

Positive and negative roles for soybean MPK6 in regulating defense responses.

It has been well established that MPK6 is a positive regulator of defense responses in model plants such as Arabidopsis and tobacco. However, the functional importance of soybean MPK6 in disease resistance has not been investigated. Here, we showed that silencing of GmMPK6 in soybean using virus-induced gene silencing mediated by Bean pod mottle virus (BPMV) caused stunted growth and spontaneous cell death on the leaves, a typical phenotype of activated defense responses.

Effects of rosuvastatin on the production and activation of matrix metalloproteinase-2 and migration of cultured rat vascular smooth muscle cells induced by homocysteine.

Objective: To test the influence of homocysteine on the production and activation of matrix metalloproteinase-2 (MMP-2) and tissue inhibitors of matrix metalloproteinase-2 (TIMP-2) and on cell migration of cultured rat vascular smooth muscle cells (VSMCs). Also, to explore whether rosuvastatin can alter the abnormal secretion and activation of MMP-2 and TIMP-2 and migration of VSMCs induced by homocysteine.

Methods: Rat VSMCs were incubated with different concentrations of homocysteine (50-5000 μmol/L).

[Influence of non-ionic surfactants on sludge dewaterability].

The water content of dewatered sludge cake decreases to about 80% by current sludge dewatering technologies, which hardly satisfies the stricter standards of sludge disposal. In order to evaluate the effects of non-ionic surfactants on sludge dewaterability, two kinds of non-ionic surfactants (OPEO and APG) were studied by using two evaluation indexes, i. e.

[Relationship of evaluation indexes of sludge dewatering performance under different conditioning programs].

Performances of different sludge conditioners are difficult to evaluate due to the use of various evaluation indexes. Taking several traditional sludge conditioners, e.g.

[Effect of Jiawei Sini Decoction on HPA function of rats with restraint psychological stress].

Objective: To observe the effect of Jiawei Sini Decoction (JWSND) on HPA function of rats with restraint psychological stress and the pathway of thymus immunosuppressive function.

Methods: The rats were randomly divided into 4 groups, control group (C), model group (M), group treated by JWSND ( C1) and ginsenosides ( C2). Hypothalamus CRH, blood plasma ACTH and CORT, the numberofthy moeyte GCR sites and the GCR nuclear translocation rate were detected by radioimmunoassay.