Rhodium(III)-catalyzed C4-amidation of indole-oximes with dioxazolones C-H activation.

A novel method for the Rh(iii)-catalyzed oxime-directed C-H amidation of indoles with dioxazolones has been developed. This strategy provides an exclusive site selectivity and the directing group can be easily removed. This transformation features a wide substrate scope, good functional group tolerance and excellent yields, and may serve as a significant tool to construct structurally diverse indole derivatives for the screening of potential pharmaceuticals in the future.

Copper-mediated direct thiolation of aryl C-H bonds with disulfides.

An efficient copper-mediated ortho-C(sp2)-H thiolation of aromatic amides directed by a novel directing group [4-chloro-2-(1H-pyrazol-1-yl)phenyl]amine has been developed without the need of other additives or oxidants, allowing for an increased usefulness. With the high compatibility of sterically demanding substrates, this reaction is scalable and can tolerate a wide scope of functional groups to provide alkyl and aryl thioethers in good to excellent yields (up to 93%). Furthermore, the protocol has been successfully implemented for the selenylation as well.

Palladium-catalyzed direct mono-aroylation of O-arylmethyl and aryl-substituted acetoxime ethers.

An efficient palladium-catalyzed ortho-aroylation of O-arylmethyl and aryl-substituted acetoxime ethers has been developed; this method has high mono-site selectivity and does not require exogenous ligands. Under the direction of a simple exo-acetoxime auxiliary, a broad scope of masked arylmethyl alcohols and phenols as well as various aromatic aldehydes are compatible with this transformation, which probably follows a mechanistic pathway involving a six- or five-membered exo-cyclopalladated intermediate. The strategy can be expediently adopted to prepare synthetically valuable 1H-benzo[d][1,2]oxazines and benzo[d]isoxazoles.

[Spectra line profile and vibrational temperature of dot and line discharge in a dielectric barrier discharge].

The emission spectrum line shift and vibrational temperature of dot and line discharges, which coexist in argon/air dielectric barrier discharge, were measured and compared. Emission spectral lines of ArI (2P2 --> 1S5) and the N2 second positive band system (C 3pi(u) --> B 3pi(g)) were used to measure the spectrum line shift and the vibrational temperature respectively. It was found that the spectrum line shift of the dot discharge channel is larger than that of the line discharge channel, indicating that the former has high electron density compared to the latter.

[Spectra line profile and vibrational temperature of bright dot and dark dot discharge in a dielectric barrier discharge].

The emission spectrum line shift and vibrational temperature of the bright dot and dark dot discharges, which are observed in the argon and air dielectric barrier discharge at high temperature for the first time were measured and compared. The line shift of the spectral line of the Ar I (2P2-->1S5) is measured and the vibrational temperature was calculated using by the emission spectral lines of the N2 second positive band system (C3Pi(u)-->B3Pi(g)). The results show that the spectrum line shift of the bright dot discharge channel is larger than that of the dark dot channel, which indicates that the former has higher electron density compared to the latter, and the vibrational temperature of the dark dot discharge channel is higher than that of the bright dot discharge channel.

[Study on plasma parameters in diffuse discharge with semispherical electrod by optical emission spectrum].

The diffuse discharge plasma in air was observed in a dielectric barrier discharge with two semispherical water electrodes. The variations of vibration temperature, rotation temperature, and average electron energy as the function of the applied voltage were studied by emission spectroscopy. The vibration temperature and the rotation temperature were calculated through the second positive band system (C3Pi(u)-->B3Pi(g)) of N2+ and the first negative band system (B2 Sigma(u+)-->Chi2Sigma(g+)) of N(2+) respectively.

[Study on spectral line profile of different types of filaments in dielectric barrier discharge].

The variations of width and shifts of Ar I (2P2 --> 1S(5)) spectral line emitted from two types of filaments, whose diameters and states are different, in argon/air dielectric barrier discharge with the change in air content were researched for the first time. In order to measure the wavelength shift, Ar I (2P2 --> 1S(5)) spectral line emitted from argon discharge at pressure of 10 Pa was used as a reference line. Regular arrangements of static wide filaments (static big dots) and moving thin filaments (reciprocating moving small dots whose traces are lines) were obtained in discharge at atmospheric pressure when the air content was in the range of 0.

[Study on spatial distribution of electron energy in hollowneedle-plate dielectric barrier discharge].

In the present work, the spatial distributions of spectrum intensity of molecule and atom in the plasma generated in hollowneedle-plate discharge in atmosphere were measured, and the spatial distribution of electron energy in plasma was analyzed. A plasma about 3 cm long is generated by using a hollowneedle-plate discharge device. By collecting optical emission spectrum from 300 to 800 nm, it was found that the spectrum consists of strong Ar I lines, strong second positive band system of N2, and weak OI line.

[Spectral analysis of different boundary discharge domain in dielectric barrier discharge].

Different discharge modes in different boundary discharge domains at the same experimental condition are observed in argon/air mixture in a dielectric barrier discharge system with two large diameter water electrodes. Regular patterns and random filaments are formed in the closed square boundary and the semiopen domain respectively. It is found that the relatively intensity of the several higher excitation energy spectral lines such as 696.

[Study of spectral line profile in a slot microplasma].

The variations of width and shift of Ar I (2P2 --> 1S5) spectral line with discharge parameters were studied in a slot microplasma. In order to measure the wavelength shift, the Ar I (2P2 --> 1S5) spectral line emitted from argon discharge at pressure of 10 Pa was used as a reference line. With the gas pressure increasing in the range of 1 x 10(4) - 6 x 10(4) Pa, the width and shift of Ar I (2P2 --> 1S5) spectral line were measured in argon (99.

Parallel approach for solution-phase synthesis of 2-quinoxalinol analogues and their inhibition of LPS-induced TNF-alpha release on mouse macrophages in vitro.

A parallel solution-phase synthesis of 2-quinoxalinol analogues is described. The key step-simultaneous reductions of m-Ar(NO2)2 to m-Ar(NH2)2 was investigated extensively. We obtained preliminary pharmacological activity of those analogues for the inhibition of LPS-induced TNF-alpha release on mouse macrophage in vitro.