Publications by authors named "Ya-fei Huo"
Article Synopsis
- A strain of infectious bronchitis virus (IBV), known as SDZB0808, was passed through chicken embryos for 110 generations to evaluate its safety and immune effectiveness.
- The 110th generation (P110) was tested on specific-pathogen-free chicks, showing no damage and 100% immunity against both the original and a different virulent strain 14 days post-vaccination.
- Genetic analysis revealed a consistent 30bp deletion in a specific region of the virus over successive generations, suggesting that the virus became less virulent, making P110 a promising candidate for an attenuated IBV vaccine.
