Association of hepatitis B virus DNA levels with efficacy and safety outcomes in patients with hepatitis B virus-associated advanced hepatocellular carcinoma receiving tyrosine kinase inhibitor plus anti-PD-1 antibody: a multicenter propensity-matched study.

Background: The efficacy and safety of tyrosine kinase inhibitors (TKIs) combined with anti-PD-1 antibodies (α-PD-1) in advanced hepatocellular carcinoma (HCC) with high hepatitis B virus (HBV) DNA levels (>500 IU/mL) remain unclear.

Methods: We retrospectively assessed patients from seven medical institutions diagnosed with HBV-related HCC, undergoing treatment with TKIs and α-PD-1 in conjunction with antiviral therapies. Based on HBV-DNA levels, patients were categorized into either high (HHBV-DNA, >500 IU/mL) or low HBV-DNA (LHBV-DNA, ≤500 IU/mL) cohorts Propensity score matching (PSM) was used to minimize baseline imbalance between groups.

Effect of Diabetes Mellitus on Implant Osseointegration of Titanium Screws: An Animal Experimental Study.

Objective: To explore the effect of diabetes mellitus (DM) on implant osseointegration of titanium screws.

Methods: Sixty rats were randomly divided into a DM group and a control group (each group, n = 30). DM group rats were injected with 1% Streptozotocin solution at 65 mg/kg to establish a DM model.

[Analysis of the factors related to glomerular filtration rate in type 2 diabetes without albuminuria].

Objective: To analyze the risk factors affecting the glomerular filtration rate (GFR) in type 2 diabetic patients without albuminuria.

Methods: A total of 131 type 2 diabetic patients with normal urinary albumin excretion rate (UAER) were divided into normal GFR group and decreased GFR group. The factors relevant to GFR were analyzed by multiple factors regression.

[Association of glycosylated hemoglobin A1c control with the complications in type 2 diabetic patients].

Objective: To investigate the status of glycosylated hemoglobin A1c (GHbA(1c)) control in type 2 diabetic patients and its relation to diabetic complications.

Methods: A total of 676 patients with type 2 diabetes were investigated for GHbA(1c) level and the diabetic complications. The patients were divided into two groups with GHbA(1c) >7% and GHbA(1c)< or =7%, and the relation of GHbA(1c) with the complications was analyzed.

[The influence of elective course of emergency treatment for medical students on the cultivation of first aid knowledge and skill of cardio-pulmonary resuscitation].

Objective: To investigate the influence of elective course of emergency treatment for medical students on the cultivation of first aid knowledge and skills of cardio-pulmonary resuscitation.

Methods: Senior students major in medicine of our university were randomly divided into observation group and contrast group with 30 students in each group according to whether an elective course of emergency treatment was given or not. All of them then received a test of first aid knowledge and cardio-pulmonary resuscitation skills.