Cytotoxic plicamine alkaloids from the whole plants of .

Phytochemical investigation on the 80% EtOH extract of the whole plants of afforded three new 4a--plicamine-type alkaloids, zephyranthines A-C (). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (HH COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. All the alkaloids were evaluated for their cytotoxic activities against six glioma cell lines (CHG5, SH-SY5Y, SHG44, U251, U343, and GL15).