Publications by authors named "Ya-Yuan Li"
Article Synopsis
- Arboviruses, specifically dengue virus serotype 2, can evolve rapidly through single nucleotide changes, leading to more severe outbreaks and replacement of existing virus strains.
- A study in Taiwan between 2001 and 2003 tracked the evolution from early epidemic strain (Ia) to later strains (Ib and II), which had key amino acid mutations that increased replication efficiency at lower temperatures.
- The findings reveal that a specific mutation in the NS5 protein boosts replication and virulence, enhancing our understanding of dengue outbreaks and helping predict future viral strains with greater epidemic potential.
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a major public health threat globally, especially during the beginning of the pandemic in 2020. Reverse transcription-quantitative PCR (RT-qPCR) is utilized for viral RNA detection as part of control measures to limit the spread of COVID-19. Collecting nasopharyngeal swabs for RT-qPCR is a routine diagnostic method for COVID-19 in clinical settings, but its large-scale implementation is hindered by a shortage of trained health professionals.
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