Thermally activated bipyridyl-based Mn-MOFs with Lewis acid-base bifunctional sites for highly efficient catalytic cycloaddition of CO with epoxides and Knoevenagel condensation reactions.

Metal-organic frameworks (MOFs) have become preferred heterogeneous catalytic materials for many reactions due to their advantages such as porosity and abundant active sites. Here, a 3D Mn-MOF-1 [Mn(DPP)(HO)]·6HO (DPP = 2,6-di(2,4-dicarboxyphenyl)-4-(pyridine-4-yl)pyridine) was successfully synthesized under solvothermal conditions. This Mn-MOF-1 possesses a 3D structure constructed by the combination of a 1D chain and the DPP ligand and features a micropore with a 1D drum-like shaped channel.

Huntington-associated protein 1 inhibition contributes to neuropathic pain by suppressing Cav1.2 activity and attenuating inflammation.

Although pain dysfunction is increasingly observed in Huntington disease, the underlying mechanisms still unknown. As a crucial Huntington-associated protein, Huntington-associated protein 1 (HAP1) is enriched in normal spinal dorsal horn and dorsal root ganglia (DRG) which are regarded as "primary sensory center," indicating its potential functions in pain process. Here, we discovered that HAP1 level was greatly increased in the dorsal horn and DRG under acute and chronic pain conditions.

The Effect of Schwann Cells/Schwann Cell-Like Cells on Cell Therapy for Peripheral Neuropathy.

Peripheral neuropathy is a common neurological issue that leads to sensory and motor disorders. Over time, the treatment for peripheral neuropathy has primarily focused on medications for specific symptoms and surgical techniques. Despite the different advantages of these treatments, functional recovery remains less than ideal.

Multilineage-differentiating stress-enduring cells alleviate atopic dermatitis-associated behaviors in mice.

Background: Pruritus is a recurring, long-lasting skin disease with few effective treatments. Many patients have unsatisfactory responses to currently available antipruritic treatments, and effective therapeutics are urgently needed to relieve symptoms. A previous study reported that mesenchymal stem cell (MSC)-mediated immune regulation could be used to treat skin inflammatory diseases.

Delayed inhibition of ERK and p38 attenuates neuropathic pain without affecting motor function recovery after peripheral nerve injury.

Peripheral nerve injuries (PNIs) often result in persistent neuropathic pain, seriously affecting quality of life. Existing therapeutic interventions for PNI-induced neuropathic pain are far from satisfactory. Extracellular signal-regulated kinases (ERKs) and p38 have been found to participate in triggering and maintaining PNI-induced neuropathic pain.

Pannexin 1, a large-pore membrane channel, contributes to hypotonicity-induced ATP release in Schwann cells.

Pannexin 1 (Panx 1), as a large-pore membrane channel, is highly permeable to ATP and other signaling molecules. Previous studies have demonstrated the expression of Panx 1 in the nervous system, including astrocytes, microglia, and neurons. However, the distribution and function of Panx 1 in the peripheral nervous system are not clear.

Activated spinal astrocytes contribute to the later phase of carrageenan-induced prostatitis pain.

Background: Prostatodynia is the main symptom of chronic prostatitis and the main reason that patients go to the hospital for treatment. Although a variety of factors, including inflammatory immune response, nervous system sensitization, and psychological factors, have been shown to play important roles in the induction and development of chronic pain in prostatitis, the underlying cause of chronic prostatodynia maintenance in prostatitis patients remains unclear.

Methods: A mouse model of chronic prostatitis induced by carrageenan injection was used.

Overexpression of P2X4 receptor in Schwann cells promotes motor and sensory functional recovery and remyelination via BDNF secretion after nerve injury.

Of the seven P2X receptor subtypes, P2X4 receptor (P2X4R) is widely distributed in the central nervous system, including in neurons, astrocytes, and microglia. Accumulating evidence supports roles for P2X4R in the central nervous system, including regulating cell excitability, synaptic transmission, and neuropathic pain. However, little information is available about the distribution and function of P2X4R in the peripheral nervous system.

Synergistic effect of SnO2/ZnWO4 core-shell nanorods with high reversible lithium storage capacity.

High reversible lithium storage capacity is obtained from novel SnO2/ZnWO4 core-shell nanorods. At C/20 (20 h per half cycle) rate, the reversible capacity of SnO2/ZnWO4 core-shell nanorods is as high as 1000 mA h g(-1), much higher than that of pure ZnWO4, SnO2, or the traditional theoretical result of the simple mixture. Such performance can be attributed to the synergistic effect between the nanostructured SnO2 and ZnWO4.