Negative genic switch of HER-2 in the primary tumor instead of the synchronous metastatic nodal lesions after neoadjuvant chemotherapy in a patient with primary HER2-positive breast cancer.

Background: A few retrospective studies have indicated that neoadjuvant chemotherapy (NAC) in breast cancer may change biomarker profiles of the primary tumor. Little is known about the status of HER-2 gene of the synchronous nodal metastases when that of the residual tumor undergoes negative conversion in a neoadjuvant setting.

Case Presentation: We describe a female patient with left breast cancer (T2N2M0) who underwent negative conversion of HER-2 in the primary tumor instead of the synchronous nodal lesions after NAC.

Image quality evaluation for CARE kV technique combined with iterative reconstruction for chest computed tomography scanning.

Background: To investigate the radiation dose and image quality for iterative reconstruction combined with the CARE kV technique in chest computed tomography (CT) scanning for physical examination.

Methods: A total of 130 patients who underwent chest CT scanning were randomly chosen and the quality reference value was set as 80 mAs. The scanning scheme was set and the patients were randomly divided into groups according to the scanning scheme.

Application Value of Selective Photon Shield in Dual-Energy Computed Tomography Angiography for Diagnosis of Intracranial Aneurysms.

Purpose: The aim of the study was to investigate the image quality of dual-energy computed tomography angiography (DECTA) using the selective photon shield (SPS) technique to diagnose intracranial aneurysms.

Materials And Methods: Eighty patients with a suspected intracranial aneurysm were randomly assigned to undergo DECTA with SPS (ie, SPS-DECTA) or DECTA without SPS (ie, DECTA). The objective image quality of these 2 groups was compared with digital subtraction angiography and surgical results as the reference.

Influence of selective photon shield combined with sinogram-affirmed iterative reconstruction on image quality and radiation dose during dual-energy CT angiography-mediated diagnosis of intracranial aneurysms.

Objective: To investigate the influence of a selective photon shield (SPS) combined with sinogram-affirmed iterative reconstruction (SAFIRE) on image quality and radiation dose during application of dual-energy CT angiography (CTA) for diagnosis of intracranial aneurysms.

Methods: We retrospectively reviewed clinical data for 80 patients with diagnoses of spontaneous subarachnoid hemorrhage. All patients underwent three-dimensional digital subtraction angiography scans within 1 week after CTA.

Synthesis of 6-alkyluridines from 6-cyanouridine via zinc(II) chloride-catalyzed nucleophilic substitution with alkyl Grignard reagents.

6-Cyanouracil derivatives underwent a direct nucleophilic substitution reaction with alkyl Grignard reagents in the presence of zinc(II) chloride as a catalyst to form the corresponding 6-alkyluracils. This methodology is applicable to sugar-protected 6-cyanouridine and 6-cyano-2'-deoxyuridine without the protection at the N(3)-imide and provides a facile and general access to versatile 6-alkyluracil and 6-alkyluridine derivatives.

BMP-2 suppresses renal interstitial fibrosis by regulating epithelial-mesenchymal transition.

Dysregulation of epithelial-to-mesenchymal transition (EMT) may contribute to renal fibrogenesis. Our previous study indicated that bone morphogenetic protein-2 (BMP-2) significantly reversed transforming growth factor (TGF)-β1-induced renal interstitial fibrosis. In this study, we examined the underlying mechanism and elucidate the regulation of EMT process under BMP-2 treatment.

[Imaging features of duplication of the internal auditory canal].

Objective: To explore multiple slices computed tomography (MSCT) and magnetic resonance imaging (MRI) features of duplication of the internal auditory canal (DIAC) in order to improve the accuracy of diagnosis.

Methods: Four cases (5 ears) were analyzed and the related documents were reviewed retrospectively. MSCT was performed on all cases, and two cases had MRI scanning at the same time.

Hyperosmolarity enhanced susceptibility to renal tubular fibrosis by modulating catabolism of type I transforming growth factor-beta receptors.

Hyperosmolarity plays an essential role in the pathogenesis of diabetic tubular fibrosis. However, the mechanism of the involvement of hyperosmolarity remains unclear. In this study, mannitol was used to evaluate the effects of hyperosmolarity on a renal distal tubule cell line (MDCK).