Publications by authors named "Ya-Xu Li"
Article Synopsis
- - Valine is a crucial branched-chain amino acid involved in various biological processes, including protein synthesis and the development of leukemia, but the way cells detect valine levels is not fully understood.
- - The study identifies human histone deacetylase 6 (HDAC6) as a valine sensor that binds directly to valine and regulates its movement between the nucleus and cytoplasm based on valine availability.
- - Findings suggest that restricting dietary valine can hinder tumor growth and improve the effectiveness of certain cancer treatments, as HDAC6's activity influences DNA demethylation and damage in response to low valine levels.
