Publications by authors named "Ya-Xin Wen"
Di (2-ethylhexyl) phthalate (DEHP) is a widely used plastics additive that growing evidence indicates as endocrine disruptor able to negatively affect various reproductive processes both in female and male animals, including humans. However, the precise molecular mechanism of such actions is not completely understood. In the present study, scRNA-seq was performed on the ovaries of offspring from mothers exposed to DEHP from 16.
View Article and Find Full Text PDF[Study on relationship between color characteristics of rhubarb charcoal in heating process and contents of 14 chemical components].
Zhongguo Zhong Yao Za Zhi
September 2020
Article Synopsis
- A high performance liquid chromatography (HPLC) method was created to simultaneously measure 14 components in rhubarb charcoal, analyzing 18 batches that were heated at varying temperatures and times.
- The 14 components analyzed fell into five categories, including gallic acid, different types of anthraquinone, and sennosides, revealing varying levels based on heating conditions.
- Color characteristics of the samples were assessed using principal component analysis (PCA), categorizing them into five types based on their degree of carbonization, and indicating changes in component levels that provide insights for evaluating heating conditions of rhubarb charcoal.
[Applicability analysis and evaluation of aglycones in single-pass intestinal perfusion technique based on PBPK model].
Zhongguo Zhong Yao Za Zhi
September 2019
Single-pass intestinal perfusion( SPIP) is the common carrier of biopharmaceutics classification system( BCS) to study compound permeability. With the application and deepening study of BCS in the field of traditional Chinese medicine( TCM),SPIP model is becoming more and more common to study the intestinal absorption of TCM ingredients. Based on the limitations of the SPIP model in some researches on TCM permeability,it was speculated in this study that aglycone may be more suitable than the glycoside to study the intestinal absorption problem by using SPIP model.
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