plus Suppress the Growth of Non-Small-Cell Lung Cancer via NLRP3/NF-B/MAPK Signaling Pathways.

(HD) plus (SB) have been widely used in antitumor clinical prescribes as one of herb pairs in China. We investigated the effect of aqueous extract from plus at the equal weight ratio (HDSB11) in inhibiting the growth of murine non-small-cell lung cancer cell (NSCLC) line LLC and in this study. Compared with other aqueous extracts, HDSB11 showed the lowest IC in inhibiting cell proliferation at 0.

Ethyl Acetate Fraction from plus Exerts Anti-Breast Cancer Effect via miR-200c-PDE7B/PD-L1-AKT/MAPK Axis.

Background: (HD) Willd. and (SB) D. Don in different ratios have been frequently used to treat various cancers in clinical Traditional Chinese Medicine prescriptions.

Ethyl Acetate Fraction from plus Suppresses Migration of Bone-Metastatic Breast Cancer Cells via OPN-FAK/ERK/NF-B Axis.

plus is a couplet of medicinal that has been commonly used to treat inflammation-related diseases and various types of tumors. However, the effect of this couplet on tumor cell migration has not been elucidated. With the aid of MCF-7-BOM, a bone-metastatic subline of ER + breast cancer MCF-7, we showed that ethyl acetate fraction extracted at an equal weight ratio of plus (EA11) inhibited cell migration of MCF-7-BOM in a concentration-dependent manner.

Mutation analysis of the Smad3 gene in human osteoarthritis.

Osteoarthritis (OA) is the most common joint disease worldwide. Recent studies have shown that targeted disruption of Smad3 in mouse results in OA. To reveal the possible association between the Smad3 gene mutation and human OA, we employed polymerase chain reaction-single strand conformation polymorphism and sequencing to screen mutations in all nine exons of the Smad3 gene in 32 patients with knee OA and 50 patients with only bone fracture.