Carnosine ameliorates age-related dementia via improving mitochondrial dysfunction in SAMP8 mice.

Dementia is a kind of age-related neurodegenerative disease. Carnosine, an endogenous dipeptide consisting of β-alanine and l-histidine, has been shown to have neuroprotective effects. However, the exact mechanism is still obscure.

Sodium tanshinone IIA sulfonate protects against Aβ-induced cellular toxicity by modulating Aβ-degrading enzymes in HT22 cells.

β-Amyloid (Aβ) plays an important role in the pathogenesis of Alzheimer's disease (AD). However, there is still no effective Aβ-targeting drugs for AD treatment. In this study, we explored the effect and mechanism of Sodium Tanshinone IIA Sulfonate (STS) on AD.