Publications by authors named "Ya-Wei Sun"
Article Synopsis
- The study addresses the rising issue of colistin-resistant bacteria, especially in Salmonella, calling for new treatment strategies as misuse of colistin increases resistance.
- Researchers focused on strain JSΔΔ/p, which showed a significant increase in susceptibility to colistin, and analyzed its genetic and metabolic profiles, finding key changes related to virulence and resistance genes.
- The findings suggest that certain metabolites (like citrate and α-ketoglutaric acid) might enhance colistin's effectiveness, and new targets (such as AcrB and CpxR) were identified that could help combat colistin resistance in bacteria.
The emergence and rapid spread of multidrug resistant (MDR) Gram-negative bacteria have posed a serious threat to global health and security. Because of the time-consuming, high cost and high risk of developing new antibiotics, a significant method is to use antibiotic adjuvants to revitalize the existing antibiotics. The purpose of the study is to research the traditional Chinese medicine baicalin with the function of inhibiting the efflux pump and EDTA whether their single or combination can increase the activity of colistin against colistin-resistant Salmonella in vitro and in vivo, and to explore its molecular mechanisms.
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- Pseudorabies virus (PRV) variants have been affecting immunized herds in China since 2011, showing that existing vaccines are not fully effective against these new strains.
- A new strain, PRV ΔgE/TK/US3, was developed by deleting the US3 gene from an earlier modified virus, PRV ΔgE/TK, and it exhibited similar growth characteristics.
- Tests on mice showed that PRV ΔgE/TK/US3 was safe and induced a strong immune response, making it a potential new vaccine candidate to combat the ongoing pseudorabies epidemic in China.
Article Synopsis
- The study focuses on using Sentinel-2 multispectral remote sensing imagery to analyze the spatial distribution of fruit tree planting for better growth monitoring, pest control, and yield estimation.
- Various vegetation indices, both conventional and improved, were utilized as input variables for a decision tree classification model that leverages machine learning technology.
- Results indicated that certain vegetation index configurations provided high accuracy for classifying fruit trees, suggesting this approach could be beneficial for large-scale monitoring of fruit tree areas using remote sensing techniques.
Our previous finding suggests that p38 MAPK contributes to the GLT-1 upregulation during induction of brain ischemic tolerance by cerebral ischemic preconditioning (CIP), however, the underlying mechanism is still unclear. Here, we investigated the molecular mechanisms underlying the CIP-induced GLT-1 upregulation by using Western blotting, Co-immunoprecipitation (Co-IP), electrophoretic mobility shift assay (EMSA) and thionin staining in rat hippocampus CA1 subset. We found that application of BAY11-7082 (an inhibitor of NF-κB), or dihydrokainate (an inhibitor of GLT-1), or SB203580 (an inhibitor of p38 MAPK) could attenuate the CIP-induced neuronal protection in hippocampus CA1 region of rats.
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- The study focuses on the plasmid pTW4 found in a strain of E. coli from a duck, which carries various antibiotic resistance genes including tet(M).
- Researchers determined the complete nucleotide sequence of pTW4 and assessed its stability and competition with the host E. coli strain.
- Although pTW4 is stable in a non-antibiotic environment, it impairs the growth of its host by 6% per ten generations, indicating a trade-off between carrying the plasmid and overall fitness.
Tet(M)-type proteins confer resistance to tetracycline and related antibiotics by interacting with the ribosome. Genes encoding Tet(M) have been found in a range of bacteria, including . In the current study, conjugation experiments were performed between seven different tetracycline-resistant, azide-susceptible strains isolated from ducks and tetracycline-sensitive, azide-resistant J53.
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- Global climate change greatly impacts extreme environments and species survival, but little is understood about how livestock, specifically sheep, have adapted genetically to these changes after domestication.
- Researchers sequenced the genomes of 77 native sheep to analyze genetic adaptations across different extreme environments, such as high altitudes and arid zones.
- The study identified candidate genes and biological pathways linked to responses to low oxygen levels and water retention, contributing valuable knowledge for future livestock breeding strategies in the context of climate change.
[Enoxaparin for the prevention of post surgical pulmonary embolism].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
November 2011
Article Synopsis
- The study aimed to assess how effective and safe enoxaparin, a low molecular weight heparin, is in preventing deep vein thrombosis (DVT) and pulmonary embolism (PE) after surgery.
- Out of 1928 surgical patients, those receiving enoxaparin had significantly lower rates of DVT (2.9% vs. 6.1%) and PE (0.3% vs. 1.4%) during hospitalization compared to the control group, and this trend continued during follow-up.
- The administration of enoxaparin was linked to slightly higher occurrences of minor and major bleeding compared to the control group, but the overall safety profile remained acceptable.*
Objective: To study the clinical effect of anterior cervical approach surgery to removal posterior longitudinal ligament (PLL) with posterior longitudinal ligament hook pliers and posterior longitudinal ligament nip pliers.
Methods: To retrospectively analyzed anterior cervical approach surgery treatment 73 patients who were cervical spondylosis myelopathy. All patients removal PLL with self-make instrument, According to JOA grade to evaluate effect of operations.
[Epidemiological survey on paragonimiasis in Ningbo City, Zhejiang Province].
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
December 2008
Article Synopsis
- Serum samples were collected from 2,643 suspected cases of paragonimiasis in Ningbo City between 2000-2007 to assess infection rates among humans and various animal hosts.
- Out of the samples tested, 417 showed positive antibodies, resulting in an overall seropositivity rate of 15.8%, with residents in endemic areas having a much lower rate between 2.8% to 3.2%.
- Infection rates in the identified intermediate hosts revealed a very low rate in snails (0.05%), a high rate in crabs (31.1%), and a moderate rate in animal reservoirs (11.9%), indicating that natural habitats for the parasite still exist in the region.
Leaves, the collective organ produced by the shoot apical meristem (SAM), are polarized along their adaxial-abaxial axis. In this study, we characterized two rice (Oryza sativa) allelic rolled-leaf mutants, rolled leaf 9-1 (rl9-1) and rl9-2, which display very similar phenotypes with completely adaxialized leaves and malformed spikelets. We cloned the RL9 gene by way of a map-based cloning strategy.
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