Protective effect of antioxidant peptides from grass carp scale gelatin on the HO-mediated oxidative injured HepG2 cells.

The protective effect of antioxidant peptides from grass carp scale gelatin on hydrogen peroxide (HO)-mediated oxidative injured HepG2 cells was investigated, and the protective mechanism as well as peptide structure were studied. Pretreated with grass carp scale gelatin hydrolysates (GSGH) for 24 h significantly increased the survival rates and decreased the apoptosis rates of HO-mediated oxidative injured HepG2 cells. The increase in SOD, CAT and GPX activities, reduce in ROS level and MDA content, and weaken in damage on cell membrane and DNA could be responsible for the protective effect of GSGH on HO-mediated oxidative injured HepG2 cells.