Pathogenesis in Transgenic Mice Expressing Bovine Cellular Retinoic Acid-Binding Protein: (transgenic/retinoic acid/CRABP/pathogenesis).

Transgenic mice with ectopic expression of bovine CRABP under the control of the human metallotheionein IIA promoter have shown a variety of pathological consequences. Expression of the transgene has been detected in most of the tissues examined, including heart, lung, liver, spleen, kidney, intestine, testis, and ovary, except pancreas. Two independent lines have been able to produce normal non-transgenic F animals of both sexes but only female transgenic progenies.