Gen-17, a beta-methyl derivative of Genipin, attenuates LPS-induced ALI by regulating Keap1-Nrf2/HO-1 and suppressing NF-κB and MAPK-dependent signaling pathways.

Background And Objective: Acute lung injury (ALI) represents a complicated and debilitating pulmonary disorder for which therapeutic options are currently limited. Genipin is an aglycone derived from the geniposide, the most abundant iridoid glucoside constituent of Gardenia jasminoides Ellis, and has demonstrated beneficial effects in ALI. The objective of this study was to investigate the protective effect of Gen-17, a beta-methyl derivative of genipin, against ALI in vitro and in vivo, and explore its mechanism of action.

Morphology and Phylogeny Reveal Three Species from China and Thailand.

Four stains were isolated from two fresh twigs of and two dead woods during investigations of micro-fungi in China and Thailand. Phylogenetic analyses of four gene regions LSU, ITS, SSU and tef1- revealed the placement of these species in . Based on the morphological examination and molecular data, two new species, and , and a known species are described.

Additions to (Amphisphaeriales, Sporocadaceae) fungi: two new species and one new host record from China.

Background: In this study, three taxa were identified, associated with leaves of , and .

New Information: Based on morphology and multi-gene analyses of the internal transcribed spacer (ITS), beta-tubulin (TUB2) and translation elongation factor 1-alpha (TEF1), the five strains of represent two novel and one known species. They are introduced with descriptions, illustrations and notes herein.

Assessment of the effectiveness of parent-targeted interventions for the use of child restraint systems: a systematic review and meta-analysis.

Background: It is essential to implement parent-targeted interventions to increase the use of child restraint systems (CRS) and thus reduce the injuries and deaths of children due to motor vehicle collisions. To optimize future intervention designs, this meta-analysis sought to quantify the effects of parent-targeted interventions and explore potential intervention moderators.

Methods: Studies met inclusion criteria if they included a parents-targeted intervention that focused on increasing CRS use for children, published from the inception of the databases to January 2022, were systematically retrieved from the PubMed, Embase, Cochrane library, Web of Science, Sinomed, Wanfang, and CNKI databases.

Modification of m6A mediates tissue immune microenvironment in calcific aortic valve disease.

Background: Several human diseases are associated with aberrant expression of regulators involved in N6-methyladenosine (m6A) RNA modification. However, their role in aortic valve calcification (AVC) is largely unknown. The aim of this study was to determine the general expression pattern and potential function of m6A regulators in AVC by bioinformatics methods.

 gen. et. sp. nov. (Pleosporales, Dothideomycetes) from medicinal plants in northern Thailand.

, a new genus, is introduced with its type species, , which was isolated from withered twigs of two medicinal plants, (Blanco) Merr (Verbenaceae) and (Hook.f.) Ridl (Rubiaceae) in northern Thailand.

Fungal diversity notes 1512-1610: taxonomic and phylogenetic contributions on genera and species of fungal taxa.

This article is the 14th in the Fungal Diversity Notes series, wherein we report 98 taxa distributed in two phyla, seven classes, 26 orders and 50 families which are described and illustrated. Taxa in this study were collected from Australia, Brazil, Burkina Faso, Chile, China, Cyprus, Egypt, France, French Guiana, India, Indonesia, Italy, Laos, Mexico, Russia, Sri Lanka, Thailand, and Vietnam. There are 59 new taxa, 39 new hosts and new geographical distributions with one new combination.

[Potassium channels and autophagy].

Potassium channels have multitudinous subtypes, which are widely distributed on cell membranes. They affect various cellular physiological functions through participating in processes such as resting potential formation, substance transportation, enzyme activity and cellular communication. Autophagy is a significant mechanism to maintain intracellular metabolic homeostasis.

Different Expression of MicroRNA-146a in Peripheral Blood CD4(+) T Cells and Lesions of Oral Lichen Planus.

Oral lichen planus (OLP) is a common T cell-mediated chronic inflammatory disease of unknown etiology. Recent increasing evidence indicates that microRNA-146a (miR-146a) plays a vital role in inflammatory diseases and T cell regulation. This study aimed to investigate the expression of miRNA-146a in peripheral blood CD4(+) T cells and local OLP lesions and to evaluate its relationship with clinical forms of OLP.

Radon concentrations in drinking water in Beijing City, China and contribution to radiation dose.

(222)Rn concentrations in drinking water samples from Beijing City, China, were determined based on a simple method for the continuous monitoring of radon using a radon-in-air monitor coupled to an air-water exchanger. A total of 89 water samples were sampled and analyzed for their (222)Rn content. The observed radon levels ranged from detection limit up to 49 Bq/L.