Anti-Inflammatory and Proangiogenic Metabolites from the Hadal Trench-Derived Fungus YP-213.

Four new compounds, including two ascochlorin-type meroterpenoids acremocholrins A () and B (), one pyridone alkaloid acremopyridone A (), and one cyclopentenone derivative acremoketene A (), together with eight known compounds (- and -), were isolated and identified from the hadal trench-derived fungus YP-213. Their structures were determined with a detailed spectroscopic analysis of NMR and MS data, NOE analysis, octant rule and quantum chemical calculations of ECD, and NMR (with DP4+ probability analysis). Among the compounds, represent a novel scaffold derived from a pyridone alkaloid by cleavage of the C-16-C-17 bond following oxidation to give a ketone.

Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32.

Three new alkaloids (1, 4 and 8), together with nine known analogues (2, 3, 5-7, and 9-12), were isolated from the marine-derived fungus Penicillium expansum Y32. Their structures including the absolute configurations were elucidated by spectroscopic and Mosher's and Marfey's methods, along with quantum electronic circular dichroism (ECD) calculations. Each of the compounds was evaluated for cardiovascular effects in a live zebrafish model.