Publications by authors named "Ya-Qin Bai"
Objectives: To screen biomarkers for forensic identification of acute myocardial infarction (AMI) by non-targeted metabolomic studies on changes of urine metabolites in rats with AMI.
Methods: The rat models of the sham surgery group, AMI group and hyperlipidemia + acute myocardial infarction (HAMI) group were established. Ultra-high performance liquid chromatography-mass spectrometry (UPLC-MS) was used to analyze the changes of urine metabolic spectrometry in AMI rats.
Objectives: To explore the differential expression of messenger RNA (mRNA) in myocardial tissues of rats with sudden coronary death (SCD), and to provide ideas for the forensic identification of SCD.
Methods: The rat SCD model was established, and the transcriptome sequencing was performed by next-generation sequencing technology. Differentially expressed genes (DEGs) in myocardial tissues of SCD rats were screened by using the R package limma.
Article Synopsis
- The study investigates how mRNA expression changes after acute myocardial infarction (AMI) in mice using the GSE4648 dataset from the Gene Expression Omnibus.
- Researchers analyzed 78 tissue samples collected at different time points (0.25, 1, 4, 12, 24, and 48 hours) to identify differentially expressed genes (DEGs) related to AMI.
- Findings revealed 1,320 DEGs linked to AMI's progression, with key genes involved in various processes such as inflammation and muscle development, potentially aiding in forensic identification of AMI.