Publications by authors named "Ya-Qian Bian"

Astragali Radix is the elixir for invigorating Qi, with the effects of invigorating Qi, promoting Yang and nourishing the body. With the deepening researches on the chemical constituents of Astragali Radix, it is used more extensively in clinical application. Based on systematic traditional Chinese medicine theory, in this paper, we characterized the effect of Astragali Radix on invigo-rating Qi from the molecular level, and explored the markers of Astragali Radix on invigorating Qi.

View Article and Find Full Text PDF
Article Synopsis
  • Traditional Chinese medicine (TCM) is commonly used to enhance blood circulation and alleviate blood stasis, but its complex composition and interactions with the human body challenge standard quality control methods.
  • This study focused on Salviae Miltiorrhizae Radix et Rhizoma, utilizing a multi-dimensional network approach to identify its efficacy markers related to blood circulation and stasis removal.
  • By leveraging databases like DrugBank and STRING, researchers pinpointed key pharmacological actions and targets, ultimately predicting potential efficacy markers such as salvianolic acid B and A, along with tanshinone Ⅱ_A and I.
View Article and Find Full Text PDF

Since February 2020, a large number of patients infected with new coronavirus has been cured and discharged with the controlling of epidemic. Pulmonary fibrosis, which may be one of the sequela caused by COVID-19, not only brings dyspnea and deterioration of lung function, but also affects patients' life because of its high mortality and poor prognosis. Vascular endothelial growth factor receptor(VEGFR) and fibroblast growth factor receptor(FGFR) can inhibit the proliferation, activation and migration of fibroblasts by regulating the signal transduction pathway involved in the process of pulmonary fibrosis.

View Article and Find Full Text PDF

The budC gene encoding a meso-2,3-butanediol dehydrogenase (BlBDH) from Bacillus licheniformis was cloned and overexpressed in Escherichia coli BL21(DE3). Sequence analysis reveals that this BlBDH belongs to short-chain dehydrogenase/reductase (SDR) superfamily. In the presence of NADH, BlBDH catalyzes the reduction of diacetyl to (3S)-acetoin (97.

View Article and Find Full Text PDF