Spin-State Control in Dysprosium(III) Metallacrown Magnets via Thioacetal Modification.

Integrating controllable spin states into single-molecule magnets (SMMs) enables precise manipulation of magnetic interactions at a molecular level, but remains a synthetic challenge. Herein, we developed a 3d-4f metallacrown (MC) magnet [DyNi(quinha)(sal)(py)](ClO) ⋅ 4HO (Hquinha=quinaldichydroxamic acid, Hsal=5-chlorosalicylaldehyde) wherein a square planar Ni is stabilized by chemical stacking. Thioacetal modification was employed via post-synthetic ligand substitutions and yielded [DyNi(quinha)(saldt)(py)](ClO) ⋅ 3HO (Hsaldt=4-chloro-2-(1,3-dithiolan-2-yl)phenol).

Designing dynamic coordination bonds in polar hybrid crystals for a high-temperature ferroelastic transition.

Ferroelastic materials have gained widespread attention as promising candidates for mechanical switches, shape memory, and information processing. Their phase-transition mechanisms usually originate from conventional order-disorder and/or displacive types, while those involving dynamic coordination bonds are still scarce. Herein, based on a strategic molecular design of organic cations, we report three new polar hybrid crystals with a generic formula of AA'RbBiCl (A = A' = MeSO for 1; A = MeSO and A' = MeN for 2; A = A' = MeNNH for 3).

A DNA small molecular probe with increasing K concentration promoted selectivity.

DNA small molecular probe study was considered as a promising approach to achieve DNA related disease diagnosis. Most related reports were performed under specific salinity. Herein, 4-imino-3-(pyridin-2-yl)-4-quinolizine-1-carbonitrile (IPQC) was generated a facile procedure with high yield (85%).

Above-Room-Temperature Ferroelastic Phase Transitions in Two Tetrafluoroborate-Based Hexagonal Molecular Perovskites.

ABX-type molecular perovskites provide an important platform to tune phase transitions, via judiciously choosing A-, B-, and X-site components, to approach advanced functional materials for applications. Although tetrafluoroborate can act as X-site component to assemble ten instances of ABX molecular perovskites, only two of them possess hexagonal perovskite structures. Herein, we report two tetrafluoroborate-based hexagonal molecular perovskites, A[Na(BF)], by judiciously choosing two different A-site cations: 1-methyl-1,4-diazabicyclo[2.

Hg(TeO)(SO): a new sulfate tellurite with a novel structure and large birefringence explored from d metal compounds.

Our exploration of novel inorganic solids with large birefringence in the d10 Metal-Te4+-SO42- system afforded four new sulfate tellurites, Ga2(TeO3)(SO4)(OH)2, In2(TeO3)2(SO4)(H2O), Zn4(Te3O7)2(SO4)2(H2O) and Hg3(Te3O8)(SO4). Notably, Hg3(Te3O8)(SO4) exhibits the largest birefringence at 532 nm (0.184) and 1064 nm (0.

BiGa(SeO): A Phase Matchable SHG Material Achieved by Cation Substitution.

The search of novel second-harmonic generation crystals in gallium selenite systems results in three new compounds of MGa(SeO) (M = Sr, Pb) and BiGa(SeO). The isostructural MGa(SeO) (M = Sr, Pb) are centrosymmetric (1̅, no. 2).

Synthesis and Evaluation of Novel 2H-Benzo[e]-[1,2,4]thiadiazine 1,1-Dioxide Derivatives as PI3Kδ Inhibitors.

In previous work, we applied the rotation-limiting strategy and introduced a substituent at the 3-position of the pyrazolo [3,4-]pyrimidin-4-amine as the affinity element to interact with the deeper hydrophobic pocket, discovered a series of novel quinazolinones as potent PI3Kδ inhibitors. Among them, the indole derivative 3 is one of the most selective PI3Kδ inhibitors and the 3,4-dimethoxyphenyl derivative 4 is a potent and selective dual PI3Kδ/γ inhibitor. In this study, we replaced the carbonyl group in the quinazolinone core with a sulfonyl group, designed a series of novel 2-benzo[][1,2,4]thiadiazine 1,1-dioxide derivatives as PI3Kδ inhibitors.

Two Indium Sulfate Tellurites: Centrosymmetric In(SO)(TeO)(OH)(HO) and Non-centrosymmetric In(SO)(TeO)F(HO).

Two new indium sulfate tellurites, namely, In(SO)(TeO)(OH)(HO) and In(SO)(TeO)F(HO), were synthesized by hydrothermal method in a one-pot reaction. Their pure phase yields have been successfully optimized to 76% and 21%, respectively. In(SO)(TeO)(OH)(HO) crystallized in centrosymmetric (CS) space group 2/, while In(SO)(TeO)F(HO) formed a non-centrosymmetric (NCS) and chiral space group 222.

Exploration of New Birefringent Crystals in Bismuth d Transition Metal Selenites.

The first examples of bismuth fluoride selenites with d -TM/Te polyhedrons, namely, Bi TiO F (SeO ) (1), Bi NbO F (SeO ) (2), Bi TeO F (TeO ) (SeO ) (3), Bi F (MoO )(SeO ) (4) and Bi ZrO F (SeO ) (5) have been successfully synthesized under hydrothermal reactions by aliovalent substitution. The five new compounds feature three different types of structures. Compounds 1-3, containing Ti , Nb and Te respectively, are isostructural, exhibiting a new 3D framework composed of a 3D bismuth oxyfluoride architecture, with intersecting tunnels occupied by d -TM/Te octahedrons and selenite/tellurite groups.

Evaluation of WO2017098421: GSK's benzothiazine compounds as CD73 inhibitor filings.

There are considerable interests in the development of novel small-molecule CD73 inhibitors for the treatment of cancers, autoimmune diseases, precancerous syndromes, and other diseases associated with CD73 activity. Areas covered: The application claims novel substituted benzothiadiazine derivatives as CD73 inhibitors for the treatment of cancer, precancerous syndromes, AIDS, autoimmune diseases, infections, atherosclerosis, and ischemia-reperfusion injury. Many of the exemplified compounds have pIC50 values between 5 to 8.

[Mn2Ga4Sn4S20](8-) T3 supertetrahedral nanocluster directed by a series of transition metal complexes.

With different transition metal (TM) complexes as structure directing agents or building units, three new multinary chalcognidometalates based on T3 supertetrahedral nanocluster of [Mn2Ga4Sn4S20](8-) have been solvothermally synthesized and structurally characterized. In compound Mn2Ga4Sn4S20[Mn2(en)5]2·4H2O (, en = ethylenediamine), the neighboring [Mn2Ga4Sn4S20](8-) cores were bridged by two pairs of [Mn2(en)5](4+) complex cations via Mn-S bonds to form one-dimensional (1D) neutral chains. Compound Mn2Ga4Sn4S20[Mn(dien)2]4·2H2O (, dien = diethylenetriamine) contained discrete [Mn2Ga4Sn4S20](8-) cores separated by [Mn(dien)2](2+) cations.