Publications by authors named "Ya-Ning Wu"
Article Synopsis
- - Non-small cell lung cancer (NSCLC) is a major health issue, and while traditional treatments like surgery and radiation have negative side effects, research into Traditional Chinese Medicine (TCM) is gaining traction due to its safer profile and potential efficacy.
- - The study aims to explore the antitumor properties of two versions of a specific TCM plant, before and after fermentation, and to understand how they inhibit NSCLC at a molecular level using various analytical techniques.
- - Results showed that the fermented version (TMQ) contained more beneficial compounds and had a greater tumor growth inhibition effect (57.24% vs. 49.62% in the unfermented version) while also affecting key proteins related to tumor growth and immune
Article Synopsis
- Xanthoceras sorbifolium seeds are valuable for both food and pharmaceutical uses, prompting a study on their chemical composition across various seed parts using advanced mass spectrometry techniques.
- The study identified 82 components in the seeds, including amino acids, polyphenols, flavonoids, and saponins, with saponins and flavonoids being most abundant in the seed kernel compared to the seed coat and shell.
- Differential analysis revealed varying concentrations of key compounds like fraxin and catechin in the seed parts, indicating that the seed coat and shell have potential for further development and research.
Paeoniflorin Ameliorates Colonic Fibrosis in Rats with Postinfectious Irritable Bowel Syndrome by Inhibiting the Leptin/LepRb Pathway.
Evid Based Complement Alternat Med
October 2022
Postinfectious irritable bowel syndrome (PI-IBS) is a highly prevalent gastrointestinal disorder associated with immune dysregulation and depression- and anxiety-like behaviors. Through traditional medicine, the active ingredient of Paeoniae Radix called paeoniflorin (PF) was previously found to prevent the symptoms of PI-IBS. However, there is limited information on the effects of PF on intestinal function and depression- and anxiety-like symptoms in PI-IBS animal models.
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- Neural decoding helps identify how and when the brain processes information, and higher accuracy in classification can extract meaningful signals from noise.
- This paper introduces a technique called empirical mode decomposition (EMD) to analyze MEG (magnetoencephalography) data, highlighting the significance of nonlinear methods in brainwave analysis.
- By applying EMD to MEG data from a facial recognition task, the study reveals previously unnoticed features and raises intriguing questions about how each hemisphere of the brain encodes facial and identity information.
Studies have suggested that visually presented words are obligatorily decomposed into constituents that could be mapped to language representations. The present study aims to elucidate how orthographic processing of one constituent affects the other and vice versa during a word recognition task. Chinese orthographic system has characters representing syllables and meanings instead of suffixation roles, and the majority of Chinese characters are phonograms that can be further decomposed into phonetic radical and semantic radical.
View Article and Find Full Text PDFTriptolide (TP), a naturally derived compound from , has been proven effective in protecting against cardiovascular system, but the molecular mechanisms underlying its protective effects are poorly understood. In the current study, we sought to test the potential protective role of TP in the regulation of vascular calcification in a rat model and explore whether TP attenuates medial vascular calcification by upregulating miRNA-204. Vitamin D3 plus nicotine (VDN) was used to induce a vascular calcification (VC) model of rat aorta.
View Article and Find Full Text PDFAngiotensin-converting enzyme has shown altered activity in patients with neurological diseases. An insertion/deletion (I/D) polymorphism of the DCP1 gene encoding angiotensin-converting enzyme has been reported to be associated with the risk for Alzheimer's disease (AD), but ambiguous results have also been presented. We conducted a case-control study in a sample composed of 192 sporadic AD patients and 195 age- and sex-matched controls from Chinese Han population in Beijing and Xi'an districts to investigate the possible effect of the polymorphism.
View Article and Find Full Text PDFPCR-RFLP was used to investigate the distribution differences of apolipoprotein E (APOE) alleles and genotypes between sporadic Alzheimer disease (AD) patients (n = 160) and healthy control individuals (n = 195) in Chinese Han population. The results showed that the allelic frequencies of APOE epsilon 2, epsilon 3 and epsilon 4 were 0.056, 0.
View Article and Find Full Text PDFThis study used case-control method to investigate roles of two alpha 2-macroglobulin (A2M) polymorphisms, a 5-bp insertion/deletion (A2M-I/D) and an A-->G substitution (A2M-A/G), in the development of sporadic Alzheimer disease (AD) in Mainland Han Chinese. Our results showed a trend of lower D-carrying genotype frequency in APOE-epsilon 4 carrying AD patients than in corresponding control subjects (chi(2)=3.67, p=0.
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