Publications by authors named "Ya-Ni Huo"
Crohn's disease (CD) is a chronic inflammatory autoimmune disease of unknown etiology. To identify new targets related to the initiation of CD, we screened a pair of twins with CD, which is a rare phenomenon in the Chinese population, for genetic susceptibility factors. Whole-exome sequencing (WES) of these patients revealed a mutation in their SERPINB4 gene.
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- Inflammatory bowel disease (IBD) is becoming increasingly common worldwide, creating a need for effective treatments, and glycerol monolaurate (GML) shows promise due to its antibacterial and anti-inflammatory properties.
- In a study, mice with DSS-induced colitis treated with GML showed improvement in symptoms, decreased expression of pro-inflammatory factors, and enhanced expression of anti-inflammatory factors, indicating a reduction in inflammation.
- GML treatment was linked to the inhibition of specific signaling pathways and improved gut health by altering the abundance of beneficial gut bacteria, suggesting a potential therapeutic role for GML in managing IBD.
Mindin is important in broad spectrum of immune responses. On the other hand, we previously reported that mindin attenuated human colon cancer development by blocking angiogenesis through Egr-1-mediated regulation. However, the mice original mindin directly suppressed the syngenic colorectal cancer (CRC) growth in our recent study and we aimed to further define the role of mindin during CRC development in mice.
View Article and Find Full Text PDFMindin has a broad spectrum of roles in the innate immune system, including in macrophage migration, antigen phagocytosis and cytokine production. Mindin functions as a pattern-recognition molecule for microbial pathogens. However, the underlying mechanisms of mindin-mediated phagocytosis and its exact membrane receptors are not well established.
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