Publications by authors named "Ya-Ni Ding"
Wnt5a promotes Kupffer cell activation in trichloroethylene-induced immune liver injury.
Toxicol Ind Health
February 2025
Article Synopsis
- Trichloroethylene (TCE) exposure can lead to a condition called trichloroethylene hypersensitivity syndrome (THS), but the mechanisms behind associated liver injuries remain unclear.
- This study investigated the role of Wnt5a and c-Jun N-terminal kinase (JNK) in liver damage caused by TCE using a sensitization model in mice, revealing that TCE exposure increased Wnt5a/JNK activity in the liver.
- Inhibiting Wnt5a and JNK lessened liver injury by reducing Kupffer cell activation and suppressing inflammatory responses, suggesting potential therapeutic approaches for managing TCE-induced liver damage.