Development and validation of a nomogram predictive model for cognitive impairment in cerebral small vessel disease: a comprehensive retrospective analysis.

Background: Cerebral small vessel disease (CSVD) is a common neurodegenerative condition in the elderly, closely associated with cognitive impairment. Early identification of individuals with CSVD who are at a higher risk of developing cognitive impairment is crucial for timely intervention and improving patient outcomes.

Objective: The aim of this study is to construct a predictive model utilizing LASSO regression and binary logistic regression, with the objective of precisely forecasting the risk of cognitive impairment in patients with CSVD.

Copper-catalyzed enantioselective diyne cyclization C(sp)-O bond cleavage.

The functionalization of etheric C-O bonds C-O bond cleavage is an attractive strategy for the construction of C-C and C-X bonds in organic synthesis. However, these reactions mainly involve C(sp)-O bond cleavage, and a catalyst-controlled highly enantioselective version is extremely challenging. Here, we report a copper-catalyzed asymmetric cascade cyclization C(sp)-O bond cleavage, allowing the divergent and atom-economic synthesis of a range of chromeno[3,4-]pyrroles bearing a triaryl oxa-quaternary carbon stereocenter in high yields and enantioselectivities.

Increasing hotspots density for high-sensitivity SERS detection by assembling array of Ag nanocubes.

Trace analysis has great promise in the fields of disease diagnosis and environment protection. Surface-enhanced Raman scattering (SERS) has wide range of utilization due to its reliable fingerprint detection. However, the sensitivity of SERS still needs to be enhanced.

[Small RNA molecules and regulation of spermatogenesis].

Small RNA molecules (small RNAs) have recently emerged as important regulators of gene expression at the post-transcriptional or translation level. Significant progress has recently been made in utilizing small RNAs to elucidate the molecular mechanisms regulating spermatogenesis. There are three major small RNAs: small interfering RNAs (siRNAs), microRNAs (miRNAs), and piwi-interacting RNAs (piRNAs).