Publications by authors named "Ya-Mei Zhu"
Article Synopsis
- Malignant ventricular arrhythmias (VA) following a myocardial infarction (MI) are linked to changes in heart electrical properties, and BRG1 plays a key role in this remodeling process.* -
- The study involved creating a mouse model of MI and using various techniques, including ECG monitoring and optical voltage mapping, to analyze the effects of BRG1 on ion channel behavior and cardiac function.* -
- Findings reveal that increased BRG1 expression after MI worsens the heart's electrical stability, while knocking down BRG1 improves conduction speed and heart rhythm, suggesting its potential as a therapeutic target for arrhythmias post-MI.*
Background And Purpose: Atherosclerosis induced by cyclosporine A (CsA), an inhibitor of the calcineurin/nuclear factor of activated T cells (NFAT) pathway, is a major concern after organ transplantation. However, the atherosclerotic mechanisms of CsA remain obscure. We previously demonstrated that calcineurin/NFAT signalling inhibition contributes to atherogenesis via suppressing microRNA-204 (miR-204) transcription.
View Article and Find Full Text PDFArticle Synopsis
- PFI-3 is a newly developed small-molecule inhibitor that selectively targets BRGs, showing potential as a therapeutic agent, though its effects on vascular function needed investigation.
- In experiments using a microvascular tension measurement device and fluorescence techniques, PFI-3 was found to cause relaxation in rat mesenteric arteries in response to various constrictors, without being influenced by certain blockers.
- The results indicated that PFI-3 reduces calcium influx and the activity of L-type voltage-dependent calcium channels in arterial smooth muscle cells, contributing to its vasodilatory effects.
Objective: The study aimed to analysis the elasticity value of placenta in healthy women during third trimester by shear wave elastography (SWE), and tried to investigate the relationship between clinical characteristics and placental elasticity.
Methods: Singleton healthy pregnant women who had routine ultrasound examination between 28 and 37 weeks were enrolled. SWE of the frontier placentas were evaluated by transabdominal ultrasound elastography.
To assess the effectiveness and safety of (TGP) on the treatment of primary Sjögren's syndrome (pSS) by conducting a meta-analysis. Eight databases were searched from their inception to December 10, 2018 for randomized controlled trials (RCTs). The Revman 5.
View Article and Find Full Text PDFPatients with rheumatoid arthritis (RA) suffer from pain, which is associated with inflammation, peripheral and central pain processing, and joint structure damage. The aim of the present study was to investigate a key microRNA (miR) and its target genes that are involved in the pain responses of RA, and to clarify the mechanism of pain regulation. Collagen‑induced arthritis (CIA) was induced in DBA/1 and C57BL/6 mice.
View Article and Find Full Text PDF[Effect of Qingluo Tongbi Compound on Osteoclast Differentiation-related mIRNA Expressions in Adjuvant Induced Arthritis Rats].
Zhongguo Zhong Xi Yi Jie He Za Zhi
October 2016
Objective To observe the effect of Qingluo Tongbi Compound (QTC) on osteoclast dif- ferentiation-related miRNA expressions in adjuvant induced arthritis (AIA) rats, and to study its mecha- nism for treating rheumatoid arthritis (RA). Methods The synovial fibroblasts and monocytes of peripher- al blood from AIA rats were co-cultured to induce osteoclast-like cells. Differently expressed miRNAs in the late stage osteoclasts differentiation were detected by miRCURY™ Array.
View Article and Find Full Text PDFObjective : The aim of study was to investigate the distribution of the integrons in Escherichia coli (E. coli) isolates, and analyze the possible relationship between the antimicrobial resistance profiles and the integrons. Methods : The antimicrobial profiles of 376 E.
View Article and Find Full Text PDF[The relationship between waist to stature ratio and hypertension, diabetes, and dyslipidemia in Qingdao].
Zhonghua Nei Ke Za Zhi
September 2012
Objective: To evaluate the relationship between waist to stature ratio (WSR) and hypertension, diabetes, dyslipidemia in Qingdao.
Methods: Data were collected from a 2001 - 2007 Qingdao area diabetes survey, population-based cross-sectional study, and 30 712 Chinese adults aged>18 years old were enrolled. Correlation analysis of BMI, WSR, hip circumference, waist circumference, waist to hip ratio (WHR) with blood glucose, blood pressure, blood lipid were conducted.