Publications by authors named "Ya-Long Xu"
Bats are well-recognized reservoirs of zoonotic viruses. Several spillover events from bats to humans have been reported, causing severe epidemic or endemic diseases including severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), SARS-CoV, Middle East respiratory syndrome-CoV (MERS-CoV), henipaviruses, and filoviruses. In this study, a novel rhabdovirus species, provisionally named Rhinolophus rhabdovirus DPuer (DPRV), was identified from the horseshoe bat (Rhinolophus affinis) in Yunnan province, China, using next-generation sequencing.
View Article and Find Full Text PDFExposure to extended periods of darkness is a common source of abiotic stress that significantly affects plant growth and development. To understand how Nicotiana benthamiana responds to dark stress, the proteomes and metabolomes of leaves treated with darkness were studied. In total, 5763 proteins and 165 primary metabolites were identified following dark treatment.
View Article and Find Full Text PDFMembrane-associated guanylate kinase (MAGUK) family protein MAGUK invert 2 (MAGI-2) has been demonstrated to be involved in the tumorigenic mechanism of prostate cancer. The objective of this study was to investigate the expression of MAGI-2 at mRNA and protein levels. The prognostic value of MAGI-2 in Han Chinese patients with prostate cancer was also investigated.
View Article and Find Full Text PDFArticle Synopsis
- Rodent populations harbor many undiscovered viruses that could potentially infect humans, prompting a study on the shedding of unknown viruses in long-tailed ground squirrels' feces.
- Researchers identified a new virus, RHV-GS2015, related to Hepacivirus, featuring a genome similar to existing hepaciviruses and showing high genetic divergence from related species.
- The study found RHV-GS2015 in multiple ground squirrel tissue samples, suggesting it is likely hepatotropic and contributing to the understanding of genetic diversity among hepaciviruses.
Article Synopsis
- Insect odorant binding proteins (OBPs) and chemosensory proteins (CSPs) are crucial for insects' chemical communication, and discovering their genes can be time-consuming, but expressed sequence tags (ESTs) from various insect species now offer a significant resource for this purpose.
- A computational method was developed to analyze 752,841 insect ESTs from 54 species, identifying 142 OBPs and 177 CSPs, including many novel ones, and validating a subset of them through RT-PCR.
- The findings highlight a large number of new OBPs and CSPs, offering insights into their evolutionary relationships and structural characteristics, and suggest that variations in conserved motifs may influence their specific functions, such as binding