[Occurrence Characteristics and Health Risk Assessment of Organophosphate Esters in Tap Water of Shanghai].

To explore the occurrence characteristics and health risk levels of the new pollutants organophosphate esters （OPEs） in tap water in Shanghai, based on the water supply areas of the Qingcaosha Reservoir, Chenhang Reservoir, Dongfeng Xisha Reservoir, and Upstream Huangpu River water sources, a total of 52 large shopping malls in Shanghai were selected as tap water sampling sites. Solid phase extraction and gas chromatography-triple quadrupole mass spectrometry were used to determine eight types of OPEs in tap water from shopping malls, including three types of chlorinated OPEs, two types of alkyl OPEs, and three types of aryl OPEs. On this basis, the health risk assessment of the substances with high detection frequency and concentration was carried out.

Overexpression of G Protein-Coupled Receptor 40 Protects Obesity-Induced Cardiomyopathy Through the SIRT1/LKB1/AMPK Pathway.

Obesity has become a serious global public health problem, and cardiomyopathy caused by obesity has recently gained attention. As an important protein involved in glucose and lipid metabolism, G protein-coupled receptor 40 (GPR40) exerts cardioprotective effects in some disease models. This study aimed to explore whether GPR40 plays a protective role in obesity-induced cardiomyopathy.

A novel sound-blocking structure based on the muffler principle for rib-sparing transcostal high-intensity focused ultrasound treatment.

The main challenge in transcostal high-intensity focused ultrasound therapy is minimising heat deposition in the ribs while ensuring that a sufficient dose is delivered to the target region. Current approaches rely on expensive multichannel phased-array systems to turn the individual transducer on and off according to either geometrical arrangements or complicated wave calculations. To protect the ribs from heating, the ultrasound energy must not only not reach the ribs, but must also not accumulate in front of the ribs.