Discovery and configurations assignment of Ile/Leu-containing cyclic peptides with cytotoxic activity, reniochpeptins A-D, from the marine sponge Reniochalina sp.

Four previously undescribed cyclic peptides, reniochpeptins A-D (1-4), were isolated from the marine sponge Reniochalina sp. Their structures were elucidated through comprehensive spectroscopic analyses and a modified advanced Marfey's method. This method utilized ultra-high-performance liquid chromatography coupled with tandem multiple reaction monitoring mass spectrometry, employing a CORTECS T column to achieve simultaneous separation of derivatized -Leu, -Ile, -allo-Ile, -Leu, -Ile, and -allo-Ile within 25 minutes in a single analytical run.

Morphology, molecular genetics, and acoustics reveal two new species of the genus from northwestern Guizhou Province, China (Anura, Megophryidae).

Two new species of the genus Smith, 1925, J. Wang, Y.L.