Prospective association of eHealth literacy and health literacy with physical activity among Chinese college students: a multiple mediation analysis.

Background: The COVID-19 pandemic has decreased physical activity (PA) while increasing demand for electronic health resources. eHealth literacy (EHL) is expected to aid eHealth use and health promotion. EHL was raised on the grounds of health literacy (HL).

Comprehensive analysis of the correlations of S100B with hypoxia response and immune infiltration in hepatocellular carcinoma.

S100B has been found to be dysregulated in many cancers including hepatocellular carcinoma (HCC). However, the functions of S100B and its underlying mechanisms in HCC remain poorly understood, especially in the tumor microenvironment. In this study, functions enrichment analysis indicated that S100B expression was correlated with hypoxia and immune responses.

Transcriptional activation of S100A2 expression by HIF-1α via binding to the hypomethylated hypoxia response elements in HCC cells.

Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancers. Dysregulation of S100A2 has recently been found in many cancers including HCC. However, its regulatory mechanism in HCC remains poorly understood, especially in hypoxia.

SPATS2 is positively activated by long noncoding RNA SNHG5 via regulating DNMT3a expression to promote hepatocellular carcinoma progression.

Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors with high mortality worldwide. Spermatogenesis-associated serine-rich 2 (SPATS2) could be a novel diagnostic and prognostic biomarker in HCC. However, the regulatory mechanism of SPATS2 in HCC requires further elucidation.

Measuring a Broad Spectrum of eHealth Skills in the Web 3.0 Context Using an eHealth Literacy Scale: Development and Validation Study.

Background: eHealth literacy (EHL) refers to a variety of capabilities that enable individuals to obtain health information from electronic resources and apply it to solve health problems. With the digitization of health care and the wide availability of health apps, a more diverse range of eHealth skills is required to properly use such health facilities. Existing EHL measurements focus mainly on the skill of obtaining health information (Web 1.

Metabolism and Tissue Distribution of Chelerythrine and Effects of Extracts on Liver NAD(P)H Quinone Oxidoreductase.

is listed as a feed additive in animal production by the European Food Authority. The metabolites of chelerythrine in rats were measured by rapid and accurate high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (HPLC/QqTOF-MS). The structures of CHE metabolites were elucidated by comparing their changes in accurate molecular masses and fragment ions with those of parent ion or metabolite.

The metabolism of gelsevirine in human, pig, goat and rat liver microsomes.

Gelsemium is a small genus of flowering plants from the family Loganiaceae comprising five species, three of which, Gelsemium sempervirens (L.) J. St.

Characterization of gelsevirine metabolites in rat liver S9 by accurate mass measurements using high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry.

Rationale: Gelsemium elegans Benth. belongs to the family Loganiaceae and is widely distributed in northern America, east Asia, and southeast Asia. It has attracted wide attention for its diverse biological effects and complex architectures.

Electrochemical Reflective Absorption Microscopy for Probing the Local Diffusion Behavior in the Electrochemical Interface.

Electrochemical interfaces determine the performance of electrochemical devices, including energy-related systems. An in-depth understanding of the heterogeneous interfaces requires in situ techniques with high sensitivity and high temporal and spatial resolution. We develop here an electrochemical reflective absorption microscope (EC-RAM) by using the absorption signals of reacting species with a reasonably good spatial resolution and high sensitivity.

Biotransformation and tissue distribution of protopine and allocryptopine and effects of Plume Poppy Total Alkaloid on liver drug-metabolizing enzymes.

In this study, the biotransformation in the plasma, urine and feces of rats following oral administration of protopine (PRO) and allocryptopine (ALL)were explored using HPLC-QqTOF MS. An HPLC-MS/MS method for the determination of tissues was developed and applied to the tissue distribution study in rats following intragastric administration of Plume Poppy Total Alkaloid for 3 weeks. A total of ten PRO metabolites and ten ALL metabolites were characterized in rats in vivo.

Identification of gelsemine metabolites in rat liver S9 by high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry.

Rationale: Gelsemine has been extensively studied because of its anti-tumor, immunomodulatory, insecticidal itching and other significant effects. However, limited information on the pharmacokinetics and metabolism of gelsemine has been reported. Therefore, the purpose of the present study was to investigate the in vitro metabolism of gelsemine in rat liver S9 by using rapid and accurate high-performance liquid chromatography/ quadrupole-time-of-flight mass spectrometry (HPLC/QqTOF-MS).

Effect of pre-exercise carbohydrate diets with high vs low glycemic index on exercise performance: a meta-analysis.

Context: Although pre-exercise consumption of a low-glycemic-index (LGI) carbohydrate meal is generally recommended, the findings regarding subsequent exercise performance are inconsistent.

Objective: This meta-analytic study was conducted to determine whether a pre-exercise LGI carbohydrate meal leads to greater endurance performance than a pre-exercise high-glycemic-index (HGI) meal.

Data Sources: The following electronic databases were searched until April 2016: MEDLINE, SPORTDiscus, Web of Science, and Cochrane Central Register of Controlled Trials.

Structural elucidation of koumine metabolites by accurate mass measurements using high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry.

Rationale: Koumine is one of the major components of total alkaloids from Gelsemium. Koumine possesses a variety of interesting pharmacological effects, including anti-tumor, anti-inflammatory, and anxiolytic activities. It might be a promising lead drug because of its pharmacological activities and mild toxicity.

Identification of allocryptopine and protopine metabolites in rat liver S9 by high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry.

Rationale: Allocryptopine (AL) and protopine (PR) have been extensively studied because of their anti-parasitic, anti-arrhythmic, anti-thrombotic, anti-inflammatory and anti-bacterial activity. However, limited information on the pharmacokinetics and metabolism of AL and PR has been reported. Therefore, the purpose of the present study was to investigate the in vitro metabolism of AL and PR in rat liver S9 using a rapid and accurate high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (HPLC/QqTOFMS) method.

Repeatability of self-report measures of physical activity, sedentary and travel behaviour in Hong Kong adolescents for the iHealt(H) and IPEN - Adolescent studies.

Background: Physical activity and sedentary behaviour are important contributors to adolescents' health. These behaviours may be affected by the school and neighbourhood built environments. However, current evidence on such effects is mainly limited to Western countries.

Metabolic and muscular responses during and after a 100 km hill walk.

Aim: Aim of the study was to assess different metabolic and muscular responses of recreational hikers during and after a hill walk of 100 km duration.

Methods: Nine subjects (6 males and 3 females) completed the 100 km hill walk within 40 hrs. Physiological and muscular responses, and biomarkers were measured during- and 18 hrs after the exercise.

Effect of glycemic index and fructose content in lunch on substrate utilization during subsequent brisk walking.

The purpose of the present study was to investigate the effect of glycemic index (GI) and fructose content in lunch on substrate utilization during subsequent brisk walking. Ten healthy young males completed 3 main trials in a counterbalanced crossover design. They completed 60 min of brisk walking at approximately 50% maximal oxygen consumption after consuming a standard breakfast and 1 of 3 lunch meals, i.

Substrate utilization during brisk walking is affected by glycemic index and fructose content of a pre-exercise meal.

The purpose of the present study was to investigate whether both glycemic index (GI) and fructose content of a pre-exercise meal would affect substrate utilization during subsequent brisk walking. Ten healthy young males completed 60 min of 46% [Formula: see text] brisk walking 2 h after they consumed one of three breakfasts: a low-GI meal without fructose (LGI), a low-GI meal including fructose (LGIF), and a high-GI meal without fructose (HGI). The calculated GI values for the three meals were 41, 39, and 72, respectively.

Reliability and validity of psychosocial and environmental correlates measures of physical activity and screen-based behaviors among Chinese children in Hong Kong.

Background: Insufficient participation in physical activity and excessive screen time have been observed among Chinese children. The role of social and environmental factors in shaping physical activity and sedentary behaviors among Chinese children is under-investigated. The purpose of the present study was to assess the reliability and validity of a questionnaire to measure child- and parent-reported psychosocial and environmental correlates of physical activity and screen-based behaviors among Chinese children in Hong Kong.

Glycemic index and glycemic load of selected Chinese traditional foods.

Aim: To determine the glycemic index (GI) and glycemic load (GL) values of Chinese traditional foods in Hong Kong.

Methods: Fifteen healthy subjects (8 males and 7 females) volunteered to consume either glucose or one of 23 test foods after 10-14 h overnight fast. The blood glucose concentrations were analyzed immediately before, 15, 30, 45, 60, 90 and 120 min after food consumption using capillary blood samples.

Effect of preexercise meals with different glycemic indices and loads on metabolic responses and endurance running.

This study examined the effect of ingesting 3 isocaloric meals with different glycemic indices (GI) and glycemic loads (GL) 2 hr before exercise on metabolic responses and endurance running performance. Eight male runners completed 3 trials in a randomized order, separated by at least 7 days. Carbohydrate (CHO) content (%), GI, and GL were, respectively, 65%, 79, and 82 for the high-GI/high-GL meal (H-H); 65%, 40, and 42 for the low-GI/low-GL meal (L-L); and 36%, 78, and 44 for the high-GI/low-GL meal (H-L).

The effect of a pre-exercise carbohydrate meal on immune responses to an endurance performance run.

This study examined the effect of a pre-exercise meal with different glycaemic index (GI) and glycaemic load (GL) on immune responses to an endurance performance run. Eight men completed a preloaded 1 h run at 70 % VO2max on a level treadmill followed by a 10 km performance run on three occasions. In each trial, one of the three prescribed isoenergetic meals, i.