Publications by authors named "Ya-Jin Xiong"
Twelve chiral compounds were enantiomerically resolved on bovine serum albumin chiral stationary phase (BSA-CSP) by high-performance liquid chromatography (HPLC) in reversed-phase modes. Chromatographic conditions such as mobile phase pH, the percentage of organic modifier, and concentration of analyte were optimized for separation of enantiomers. For N-(2, 4-dinitrophenyl)-serine (DNP-ser), the retention factors (k) greatly increase from 0.
View Article and Find Full Text PDFThe chiral discrimination studies of biological system are theoretically and practically significant for the development of chiral drugs and life science. Our work has embarked upon the interaction between serum albumin (SA) (including human SA and bovine SA), R,S-1-(4-methoxyphenyl)ethylamine, and R,S-1-(3-methoxyphenyl)ethylamine. The formation of intermediate transition state, binding sites, and chiral discrimination ability can be investigated by ultraviolet-visible spectra and fluorescence spectra.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on creating new chiral stationary phases by chemically immobilizing a specific β-cyclodextrin derivative onto amino-functionalized silica gel with varying pore and particle sizes.
- It examines how different silica gel characteristics affect the amount of immobilized material, column performance, and the ability to separate enantiomers.
- Results showed that smaller pore sizes and finer silica gel particles (3 μm) improved retention, resolution, and overall performance in separating racemates in both separation modes.