Publications by authors named "Ya-Jia Li"
Background: Severe heart failure (HF) has a higher mortality during vulnerable period while targeted predictive tools, especially based on drug exposures, to accurately assess its prognoses remain largely unexplored. Therefore, this study aimed to utilize drug information as the main predictor to develop and validate survival models for severe HF patients during this period.
Methods: We extracted severe HF patients from the MIMIC-IV database (as training and internal validation cohorts) as well as from the MIMIC-III database and local hospital (as external validation cohorts).
Article Synopsis
- The study aimed to explore how proton pump inhibitors (PPIs) given during hospital stays affect mortality and length of stay among critically ill pediatric patients in the ICU.
- Analyzing data from 2,269 pediatric ICU patients, the findings indicated that omeprazole use was linked to shorter ICU stays but longer stays in the hospital overall; no significant reduction in mortality was observed, although slight decreases were noted, especially in patients under one year old.
- The researchers concluded that using PPIs specifically in the ICU might be more beneficial than using them throughout the entire hospital stay, particularly for younger patients.
Background: Although numerous studies confirmed the marked efficacy of chimeric antigen receptor T cells (CAR-T cells) in many hematologic malignancies, severe cardiovascular toxicities remain to be a major obstacle when incorporating this technology. Furthermore, previous individual investigations regarding the cardiovascular toxicities of CAR-T cell therapy also reported controversial conclusions. Therefore, a meta-analysis was performed to further evaluate the impacts of CAR-T cell therapy on cardiovascular toxicities.
View Article and Find Full Text PDFObjectives: The current world witnesses a greatly increased prevalence and incidence of hyperuricemia and gout with unfortunately the comparative efficacy and safety of present available uricosuric agents remaining uncertain. We herein aimed to investigate the most appropriate uricosuric agent for gout or hyperuricemia patients.
Method: PubMed, Embase, Cochrane Library databases, and ClinicalTrials.
Aim: To discuss the clinical characteristics of immune-related dry eye.
Methods: Simple dry eye (SDE) group: we selected 224 patients of simple dry eye with no systemic lesions. Immune-related dry eye (IRDE) group: we selected 207 patients of dry eye complicated with immune system diseases, including 70 cases of Sjögren's syndrome (SS), 72 cases of systemic lupus erythematosus (SLE), and 65 cases of rheumatoid arthritis (RA).