The role of GLP-1/GIP receptor agonists in Alzheimer's disease.

Background: New glucagon-like peptide-1 (GLP-1) analogues developed in recent years have a long half-life and offer further prospects for clinical application. At present, the neuroprotection of GLP-1 analogues in Alzheimer's disease (AD) has just begun to be explored.

Objectives: To investigate how glucagon-like peptide-1 (liraglutide) plays a protective role in AD by regulating tau activation and BACE1 expression.

Non alcoholic steatohepatitis a precursor for hepatocellular carcinoma development.

Hepatocellular carcinoma (HCC) is increasing in prevalence and is one of the most common cancers in the world. Chief amongst the risks of attaining HCC are hepatitis B and C infection, aflatoxin B1 ingestion, alcoholism and obesity. The later has been shown to promote non alcoholic fatty liver disease, which can lead to the inflammatory form non alcoholic steatohepatitis (NASH).

Development and validation of a capillary zone electrophoresis method for the determination of benzalkonium chlorides in ophthalmic solutions.

A systematic investigation of optimal conditions for determining the benzalkonium chlorides in ophthalmic products by capillary zone electrophoresis (CZE) was presents. The most effective separation conditions was 40 mM phosphate buffer with 40% acetonitrile at pH 4.0, and the sample hydrodynamic injection of up to 10 s at 2 p.