Publications by authors named "Ya-Han Chuang"
Article Synopsis
- mRNA vaccines can be limited in effectiveness due to liver accumulation when delivered via lipid nanoparticles (LNPs); this study introduces an oral formulation that targets immune cells in the gastrointestinal tract.
- The new vaccine, βGlus/mRNA@LNPs, combines mRNA with β-glucans and utilizes LNPs to protect the mRNA from degradation in the GI environment while allowing for immune cell uptake.
- Testing showed that this oral vaccine triggers strong immune responses in tumor-bearing mice without significant side effects, offering a promising, easy-to-administer alternative in cancer immunotherapy.
The development of treatments for critical-sized bone defects has been considered an important topic in the biomedical field because of the high demand for transplantable bone grafts. Following the concept of tissue engineering, implantation of biocompatible porous scaffolds carrying cells and regulating factors is the most efficient strategy to stimulate clinical bone regeneration. With the advancement in the development of 3D-printing techniques, scaffolds with highly controllable architectures can be fabricated to further improve healing efficacies.
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