Publications by authors named "Ya-Guang Zhou"
Hypoxic pulmonary vasoconstriction (HPV) can be modulated by Rho/Rho kinase signaling, which can alter HPV vascular function via regulating myosin light chain phosphorylation, in a manner generally believed to be Ca-independent. We hypothesized that the RhoA/ROCK signaling pathway also can regulate HPV vascular function via a Ca-dependent mechanism, signaling through the functional transient receptor potential canonical (TRPC) channels. In this study, male BALB/c mice were exposed to normoxic or 10% oxygen (hypoxic) conditions for six weeks, after which systolic pressure and right ventricular hypertrophy were assessed.
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- The study examines the link between chemotherapy-associated hemoglobin levels and survival outcomes in colorectal cancer (CRC) patients undergoing adjuvant FOLFOX chemotherapy.
- Researchers found that a hemoglobin level below 90 g/L is a significant predictor of poorer disease-free survival (DFS) and overall survival (OS).
- The findings suggest that monitoring hemoglobin levels could be important for personalized treatment strategies in CRC, particularly in addressing anemia during chemotherapy.
Objective: To study the effect of tanshinone II A on the cell signal transduction system protein kinase B (Akt) in rats with hypertrophy of the myocardium induced by partial constriction of the thoracic aorta.
Methods: Rat models of myocardial hypertrophy were established by the thoracic aorta partial constriction method. Forty-eight rats were randomly divided into the sham-operative group, the model group, the valsartan treatment group, and the low-, medium-, and high-dose tanshinone treatment groups.