Publications by authors named "Ya-Fei Hu"
Does the size of the neuroendocrine-carcinoma component determine the prognosis of gallbladder cancer?
Front Endocrinol (Lausanne)
August 2024
Background: Gallbladder mixed neuroendocrine-non-neuroendocrine neoplasm generally consists of a gallbladder neuroendocrine tumor and a non-neuroendocrine component. The World Health Organization (WHO) in 2019 established a guideline requiring each component, both neuroendocrine and non-neuroendocrine, to account for a minimum of 30% of the tumor mass.
Methods: Patients after surgery resection and diagnosed at microscopy evaluation with pure gallbladder neuroendocrine carcinoma (GBNEC), gallbladder mixed adeno-neuroendocrine carcinoma (GBMANEC, GBNEC≥30%), and gallbladder carcinoma mixed with a small fraction of GBNEC (GBNEC <30%) between 2010 and 2022 at West China Hospital of Sichuan University were collated for the analyses.
Article Synopsis
- A new strategy was created to transform β-trifluoromethyl enones through a three-step process: carbonyl reduction, hydrodefluorination, and defluoroamination, all without using transition metals.
- This approach successfully produced useful α-fluoroenamides in high yields, which can further be converted into important organofluorides and heterocycles.
- The carbonyl group aids in the reaction by affecting both the electronic and steric properties of the molecules, making the defluorination process more controllable and selective.
Article Synopsis
- Intrahepatic cholangiocarcinoma (ICC) is a serious type of cancer that affects the liver, and researchers are trying to understand how the tumor environment interacts with different cells.
- They used a special method to find out which genes are important in the tumor and how cells communicate with each other.
- The study found that certain gene scores related to cancer cells can predict how well patients will do, and they discovered specific ways that certain cells interact, which might help in developing better treatments.
Objective: The efficacy of platinum-based chemotherapy (PtCh) for pancreatic cancer (PC) patients with DNA damage repair gene mutations (DDRm) compared to those without DDRm remains uncertain.
Methods: After a thorough database searching in PubMed, Embase, and Web of Science, a total of 19 studies that met all the inclusion criteria were identified. The primary outcomes were overall survival (OS) and progression-free survival (PFS) for PC patients with DDRm versus those without DDRm after PtCh.
Outcomes of laparoscopic liver resection (LLR) versus open LR (OLR) for intrahepatic cholangiocarcinoma (ICCA) are heterogeneous. We aimed to compare LLR and OLR for ICCA based on propensity-score-matched (PSM) studies. Two reviewers independently searched the online databases (PubMed, Embase, and Cochrane Library) for PSM studies that compared LLR and OLR for ICCA.
View Article and Find Full Text PDFArticle Synopsis
- Gallbladder neuroendocrine carcinoma (GBNEC) is a rare and poorly differentiated tumor, and its clinical characteristics compared to gallbladder adenocarcinoma (GBADC) are debated.
- In a study of 201 GBADC and 36 GBNEC cases, GBNEC patients were found to be younger and more likely to present with advanced tumor stages, as well as higher rates of perineural invasion (PNI) and lymphovascular invasion (LVI).
- Although GBNEC patients initially showed worse survival outcomes than those with GBADC, after matching for various factors (propensity score matching), their overall and recurrence-free survival rates were similar, with significant pathological features influencing prognosis instead.
A chemo-, regio-, and stereoselective reaction of trifluoromethyl enones, phenylsilane, and phosphine oxides through a sequential hydrodefluorination and defluorophosphorylation relay is developed for the synthesis of distinctive -fluorophosphine alkenes. This multicomponent reaction occurred under transition-metal-free conditions with good functional group tolerance. Moreover, the preinstalled carbonyl auxiliary is important for tuning the reactivity of β-trifluoromethyl enones, thereby enabling controllable and selective functionalization of two fluorine atoms in trifluoromethylated enones.
View Article and Find Full Text PDFThe auxiliary function of a carbonyl group in the tunable defluorophosphination and defluorophosphorylation of trifluoromethylated enones with P(O)-containing compounds was demonstrated. Controlled replacement of one or two fluorine atoms in trifluoromethylated enones while maintaining high chemo- and stereoselectivity was achieved under mild conditions, thus enabling diversity-oriented synthesis of skeletally diverse organophosphorus libraries─()-difluoro-1,3-dien-1-yl phosphinates, (1,3)-4-phosphoryl-4-fluoro-buta-1,3-dien-1-yl phosphinates, and ()-4-phosphoryl-4-fluoro-1,3-but-3-en-1-ones─in good yields with excellent functional group tolerance.
View Article and Find Full Text PDFObjective: To evaluate the efficiency of laparoscopic surgery in treating recurrent liver tumors vs. conventional open surgery.
Methods: Database searching was conducted in PubMed, the Cochrane Library and EMBASE.
Background: Some studies have pointed out that a wide resection margin can improve the prognosis of intrahepatic cholangiocarcinoma, but some researchers disagree and believe that a wide margin may increase complications. The optimal margin length of intrahepatic cholangiocarcinoma is controversial.
Method: The literature was searched in PubMed, MedLine, Embase, the Cochrane Library, and Web of Science until December 31, 2021, to evaluate the postoperative outcomes of patients with different margin width after resection.
Evidence regarding the optical surgical extent for Bismuth type I/II HCCA is lacking. we aims to evaluate the optimal surgical methods for Bismuth type I/II HCCA. Studies comparing bile duct resection (BDR) and BDR combined with liver resection (BDR + LR) for all types of HCCA patients were searched for analyses, and 14 studies were finally included.
View Article and Find Full Text PDFObjective: To evaluate the consistencies and inconsistencies between distal cholangiocarcinoma (DCCA) and pancreatic ductal adenocarcinoma (PDCA) regarding their biological features and long-term prognosis.
Methods: PubMed, the Cochrane Library, and EMBASE were searched to find comparative studies between DCCA and PDCA. RevMan5.
Article Synopsis
- The study investigates the diagnosis, treatment, and outcomes of gallbladder sarcomatoid carcinoma (GBSC) patients, analyzing data from 50 surgical cases collected between 2000 and 2020.
- Findings reveal a median overall survival of 14.5 months with significant differences in survival rates based on the type of surgery performed, highlighting that radical resection leads to better outcomes compared to palliative surgery.
- The research concludes that due to the aggressive nature of GBSC, timely surgery and postoperative chemotherapy are crucial for improving patient survival, with S-1-based chemotherapy demonstrating higher effectiveness in prolonging recurrence-free survival.
[Effects of p,p'-DDE and beta-BHC on the apoptosis of Sertoli cells in vitro].
Zhonghua Yu Fang Yi Xue Za Zhi
September 2008
Objective: To explore the effects of p,p'-DDE and beta-BHC on the apoptosis of Sertoli cells in vitro via activation of Caspase.
Methods: Sertoli cells were treated in vitro for 24 hours with a serial concentrations of p,p'-DDE (10, 30 and 50 micromol/L), beta-BHC (10, 30 and 50 micromol/L) and p,p'-DDE + beta-BHC (10, 30 and 50 micromol/L). The inhibitory group was first treated with 100 micromol/L Caspase-3 inhibitor Ac-DEVD-CHO treating for 2 hours before 50 micromol/L p, p'-DDE + 50 micromol/L beta-BHC 24 hours-treatment.
Objective: To study the action mechanism of p,p'-DDE and/or beta-BHC on JNK and MAPK signal transduction pathways in rat Sertoli cells in vitro.
Methods: We cultured the Sertoli cells isolated from rat testicular tissues for 2 days in vitro, divided them into a control group incubated with DMSO and 3 case groups exposed to p,p'-DDE and / or beta-BHC at the final concentration of 10, 30, 50 micromol/L for 24 hours, and then detected the expression levels of JNK and c-jun mRNA by two-step RT-PCR.
Results: Twenty-four hours after p,p'-DDE treatment, the grayscale values of JNK mRNA were 0.