Design, synthesis, evaluation and molecular modeling study of 4-N-phenylaminoquinolines for Alzheimer disease treatment.

Dual binding site acetylcholinesterase (AChE) inhibitors and butyrylcholinesterase (BChE) inhibitors have recently emerged as two classes of new anti-Alzheimer agents to positively modify the disease's course. In this work, a new series of 4-N-phenylaminoquinolines was synthesized and evaluated for their abilities to inhibit AChE and BChE. Compound 11b showed significant inhibitory activities on AChE and BChE with IC values of 0.

A new classification and clinical results of Gamma Knife radiosurgery for cavernous sinus hemangiomas: a report of 53 cases.

Background: Cavernous sinus hemangiomas (CaSHs) are rare vascular lesions in the cavernous sinus(CS). Gamma Knife radiosurgery (GKS) provides a treatment modality alternative to microsurgery. This study was conducted to describe a new classification of CaSHs based on their magnetic resonance (MR) imaging findings and determine the efficacy and safety of GKS in a large series of CaSH patients.

[Gamma knife for elderly patients with large vestibular schwannomas: 11-year follow-up].

Objective: To evaluate the effect of Leksell Gamma Knife (LGK) on elderly patients with large vestibular schwannomas (VS) and to summarize the indications for LGK in patients with large VS.

Methods: From July 1994 to July 2000, 50 elderly patients (age range: 60.0 - 81.

[Gamma knife radiosurgery for large trigeminal schwannomas].

Objective: To evaluate the role of gamma knife (GK) radiosurgery in controlling large trigeminal schwannoma.

Methods: The clinical data of 30 patients suffering from large trigeminal schwannoma with a maximum diameter of 39.0 mm (31.

The long-term results of gamma knife radiosurgery for hemangioblastomas of the brain.

Object: The authors assessed the long-term result of gamma knife surgery (GKS) for hemangioblastomas of the brain (HABs) and show histopathological findings after GKS.

Methods: Thirty-five patients, 28 men and seven women, with a mean age of 36 years underwent GKS. Eighteen patients presented with multiple tumors and 17 with a solitary tumor.

Long-term results of Leksell gamma knife surgery for trigeminal schwannomas.

Object: The authors evaluated the long-term efficacy of gamma knife surgery (GKS) in patients with trigeminal schwannomas.

Methods: Fifty-six patients, 31 women and 25 men (mean age 42 years), underwent GKS for trigeminal schwannomas. Fourteen had previously undergone surgery, and GKS was the primary treatment in the remaining 42 patients.

[Analysis of the results of gamma knife radiosurgery for hemangioblastomas of the brain and the factors related to the tumor recurrence].

Objective: To assess the 5-year-result of leksell gamma knife (LGK) in controlling hemangioblastomas of the brain (HB) and to analyze the factors related to tumor recurrence or development of new tumors.

Methods: From November 1993 to September 2001, 35 patients, 28 males and 7 females, aged 36 (16 approximately 61), 18 with multiple tumors and 17 with solitary tumor, the number of tumors being 93 in total, were treated by LGK. Twenty-one patients with HBs were associated with von Hippel-Lindau disease (VHLD).

[Gamma knife radiosurgery for trigeminal schwannomas].

Objective: To evaluate the role of gamma knife (GK) in the treatment of trigeminal schwannomas.

Methods: From June 1994 to June 2000, 38 patients with trigeminal schwannoma treated with GK radiosurgery were reviewed. GK was the primary treatment modality in 30 cases and followed microsurgery in 8 cases.