Publications by authors named "Ya-Chun Tu"
Ischemia-reperfusion injury (IRI) contributes to acute kidney injury (AKI) and development of chronic kidney disease. We describe an IRI protocol for mice via flank incisions approach, using a pedicle clamp to cause ischemic injury. Compared with trans-abdominal approach, it is technically easier with lesser fluid loss and organ injury.
View Article and Find Full Text PDFThe use of medium cut-off (MCO) polyarylethersulfone and polyvinylpyrrolidone blend membrane is an emerging mode in hemodialysis. Recent studies have shown that MCO membranes exhibit a middle high molecular weight uremic toxin clearance superior to standard high flux hemodialysis. We conducted a systematic literature review and meta-analysis of randomized controlled trials to investigate whether MCO membranes efficiently increase the reduction ratio of middle molecules, and to explore the potential clinical applications of MCO membranes.
View Article and Find Full Text PDFObjectives: To examine whether urinary excretion of cysteine-rich protein 61 (Cyr61), an acknowledged proinflammatory factor in kidney pathologies, increases in chronic kidney disease (CKD) and is associated with subsequent rapid kidney function decline.
Design: An observational cohort study.
Setting: In the nephrology outpatient clinics of a tertiary hospital in Taiwan.
Article Synopsis
- Klebsiella pneumoniae is the leading cause of primary liver abscess, but there’s still a limited understanding of how it infects the liver.
- A genetic screening of 2,880 K. pneumoniae mutants identified 28 strains with reduced growth in mouse liver or spleen, revealing the importance of genes related to metabolism, adhesion, and regulation for liver abscess development.
- The study found that certain mutant strains could protect mice from K. pneumoniae infections, suggesting their potential use in creating vaccines or preventive treatments.
Bar arrangements used by conventional diffractive barcodes are usually similar to those used by diffusive barcodes. We, however, propose a modified diffractive barcode with bar arrangements different from those used by diffusive barcodes. A modified diffractive barcode pattern is composed of many parallel grating-dot lines.
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