Early changes to dry eye and ocular surface after small-incision lenticule extraction for myopia.

Aim: To investigate the early changes in dry eye symptoms, tear function and ocular surface following small-incision lenticule extraction (SMILE) for myopia.

Methods: Ninety-seven consecutive patients (193 eyes) who underwent SMILE for myopia were observed in this longitudinal and retrospective study. Parameters evaluated included: subjective dry eye symptoms (dryness, foreign body sensation and photophobia), tear film breakup time (TBUT), Schirmer I test (S I T) without anesthesia, tear meniscus height (TMH) and corneal fluorescein staining.

[Clinical evaluation of laser in situ keratomileusis operation with three different ablative patterns].

Objective: To evaluate the clinical outcome among three different laser in situ keratomileusis (LASIK) ablations: Q-factor customized ablation (aberration smart ablation, ASA), wave-front guided ablation (WASCA) and ablation under wave-front guiding plus iris recognition system (IR+WASCA).

Methods: This prospective study comprised 96 eyes of 96 patients, and they were randomly divided into three groups: 30 patients in ASA group, 32 in WASCA group, and 34 in IR+WASCA group. There were no any statistical differences in spherical equivalent (SE), age, sex, pupil diameter, higher-order aberrations (HOA) among three groups preoperatively.

[Present status of genome-wide association studies and its applications in ophthalmology].

Genome-wide association studies (GWAS) assay a dense set of single-nucleotide polymorphisms (SNPs) in whole genome and relate them to various diseases and measurable traits. The completion of Human Genome Project and Human Haplotype Map Project has made this approach possible. Genome-wide association studies have identified a large number of robust associations between genetic variants and common diseases.

[The autonomic pupillary dysfunction in type II diabetes mellitus].

Objective: To evaluate the pupillary disorder associated with autonomic neuropathy of type II diabetes mellitus by investigating pupil diameters under mesopic, photopic and pharmacologically dilated conditions.

Methods: Forty of type II diabetic patients were divided into two groups based on the results of fundus fluorescein angiography, one group was the subclinic diabetic retinopathy and another was the NPDR (nonproliferative diabetic retinopathy), 20 age-matched healthy subjects were selected as control. High-resolution images of the pupil in 60 subjects were taken using an infrared-sensitive camera under mesopic, photopic and pharmacologically dilated conditions, respectively.

Bilateral comparison of conventional versus topographic-guided customized ablation for myopic LASIK with the NIDEK EC-5000.

Purpose: To compare visual acuity and higher order aberrations before and after myopic LASIK using conventional versus customized ablation.

Methods: This prospective, randomized study included 54 myopic eyes in 27 patients who underwent bilateral LASIK using the NIDEK EC-5000 excimer laser system (NIDEK Technologies, Gamagori, Japan). Customized aspheric treatment zone (CATz) treatment was used in one eye (CATz group) and conventional ablation (conventional group) was used in the fellow eye.