Dopamine D2 receptor on CD4 T cells is protective against inflammatory responses and signs in a mouse model of rheumatoid arthritis.

Background: Dopamine is a neurotransmitter and has been found to regulate lymphocytes by acting on dopamine receptors (DRs). CD4 T cells express all the five subtypes of DRs, D1R to D5R. Although CD4 T cells have been involved in pathogenesis of rheumatoid arthritis (RA), roles of DRs expressed on these cells in RA are poorly understood.

Xiaoaiping injection combined with chemotherapy for advanced gastric cancer: An updated systematic review and meta-analysis.

To evaluate the clinical efficacy and safety of Xiaoaiping injection combined with chemotherapy in the treatment of advanced gastric cancer by meta-analysis. Seven databases, including China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Database, Cochrane Library, PubMed, Embase, and Web of Science, were searched by computer for randomized controlled clinical trials of Xiaoaiping injection combined with chemotherapy in the treatment of gastric cancer. Risk of bias assessment and meta-analysis were performed by Review Manager 5.

Efficacy of gecko polysaccharide on suppressed immune response induced by cyclophosphamide in mice.

Objective: To evaluate the efficacy of gecko polysaccharide on the cyclophosphamide-induced suppressed immune response in mice.

Methods: Polysaccharides were extracted from fresh gecko for the first time using an orthogonal method and protein was removed using Sevag reagent (chloroform:N-butanol, 5:1, v/v). The gecko polysaccharide (GPCE) content was determined by the phenol-concentrated sulfuric acid method.