Spatiotemporal characteristics and influencing factors of non-CO greenhouse gas emission intensity from China's livestock sector.

The livestock sector is a major source of non-CO greenhouse gas (GHG). As China has the world's largest livestock production, analyzing factors influencing GHG emission intensity of livestock (GEIL) is crucial for guiding its emission reduction policies. Yet, most current studies on livestock GHG focus on emission amount (GEAL) over GEIL, neglecting comprehensive utilization of spatial econometric models.

Balanced water and heat energy recycling by full evaporation of wastewater (FEW) in dry biorefining processes of lignocellulose biomass.

Lignocellulosic biorefinery technology requires minimum energy consumption and wastewater generation to overcome challenges in industrial applications. This study established a rigorous model and a comprehensive physical property database of dry biorefining process on Aspen Plus platform for production including L-lactic acid, citric acid, sodium sugar acids, amino acid, and ethanol based on the experimental data. Full evaporation of wastewater (FEW) approach was proposed to completely replaced the external steam supply, and significantly reduced the freshwater input by 67% ∼ 85% and wastewater generation by 64% ∼ 89%, depending on the specific products.

A potential pathogenic mutation of LAMA4 in a Chinese family with dilated cardiomyopathy and conduction system disease.

Dilated cardiomyopathy (DCM) is characterized by ventricular dilation and poor systolic function. Approximately half of idiopathic DCM cases are assigned to genetic causes in familial or apparently sporadic cases, and more than 50 genes are reported to cause DCM. However, genetic basis of most DCM patients still keeps unknown and require further study.

A cationic AIE luminutesogen TBPD-6C as a potential bacterial detection agent and bactericide for plants bacterium.

The rise of plant bacterial pathogens poses a significant threat to the yield and quality of essential food crops and cash crops globally. Our research introduced a versatile cationic AIE fluorescent probe for detecting and eliminating plant bacteria. With its unique aggregation-induced emission property, TBPD-6C can effectively detect plant bacteria by causing a fluorescence quenching effect and enables bacterial imaging under green fluorescence channels.

Biodegradable silk fibroin membranes for potential localized treatment of melanoma: optimized preparation andstudy.

As a lethal skin cancer, melanoma is highly aggressive and metastatic with high recurrence rates and the common therapy is surgical resection followed by chemotherapy. To minimize the side effects of chemotherapeutic drugs and prevent tumor recurrence, localized therapy is a more suitable treatment method. Here, a fully biodegradable silk fibroin (SF) membrane loaded with the therapeutic drug doxorubicin (Dox) is fabricated for potential localized chemotherapy of melanoma.

Benzotrithiophene-Based Covalent Organic Frameworks with Rhenium Modified for Artificial Photosynthetic CO Reduction.

Although covalent organic framework (COF)-based photocatalysts for CO reduction reaction has been widely reported, there are still some problems such as poor visible-light absorption and low activity to realize the overall reaction of CO reduction by the artificial photosynthesis strategy. Herein, anchoring the Re carbonyl complex Re(CO)Cl in a benzotrithiophene-based COF has been synthesized for artificial photosynthetic CO reduction. The photocatalytic results demonstrate that BTT-bpy-COF-Re exhibits the highest CORR activity, achieving a rate of 110.

Versatile inulin/trans-ferulic acid/silk sericin nanoparticles-nourished probiotic complex with prolonged intestinal retention for synergistic therapy of inflammatory bowel disease.

To achieve effective long-term synergistic treatment of inflammatory bowel disease (IBD) with probiotics, we developed a versatile inulin/trans-ferulic acid/silk sericin nanoparticles-nourished probiotic complex. Inulin/TFA/SS nanoparticles were fabricated by inulin, trans-ferulic acid (TFA), and silk sericin (SS), and then loaded onto the surface of poly-l-lysine (PLL) and poly-glutamic acid (PGA)-coated Bifidobacterium longum (BL) to obtain BL@PLL-PGA-Inulin/TFA/SS NPs (BL@PP-NPs). This design simultaneously endowed the complex with excellent gastrointestinal resistance, antioxidant, and anti-inflammation abilities.

Anti-hyperuricemic effects of the seeds of Hovenia acerba in hyperuricemia mice.

Ethnopharmacological Relevance: The seeds of Hovenia acerba water extract (HAW) are used as an edible traditional Chinese medicine to treat diseases related to hyperuricemia (HUA).

Aim Of The Study: To evaluate HAW for its anti-HUA effect and to figure out their underlying mechanisms.

Materials And Methods: The anti-HUA effects were evaluated on a mouse model by testing HAW's effects on the levels of serum uric acid (SUA), the biochemical indicators of liver and kidney function, and the histology of liver and kidney.

Drivers of environmental externality reduction in China's electric power industry: A spatial-temporal analysis.

China's electric power industry has made significant efforts to reduce environmental externality in the past two decades. However, the extent of the reduction, the driving factors behind it, and the regional performance are not well clarified. This study constructs a comprehensive framework that integrates the impact pathway approach with index decomposition analysis to explore the driving factors behind the reduction of environmental externality from a spatial-temporal perspective.

Optimal repetitive readout of single solid-state spins determined by Fisher information.

Quantum systems, including superconducting circuits, trapped ions, quantum dots, solid-state defects, etc., have achieved considerable advancements in readout fidelity. However, the widely used threshold method disregards the importance of temporal characteristics of the signal during continuous measurements, leading to information loss.

Intraretinal Retinal Pigment Epithelium Cells in Age-Related Macular Degeneration.

Purpose: To examine intraretinally migrated retinal pigment epithelium cells (iRPECs) in enucleated human eyes with various retinal conditions and corresponding intraretinal hyperreflective bodies (iHRBs) in a large cohort of patients with age-related macular degeneration (AMD) in China.

Design: Population-based study and histomorphometric investigation.

Participants: Participants of the population-based Beijing Eye Study and enucleated human eyes.

Stephanine Protects Against Osteoporosis by Suppressing Osteoclastogenesis via Inhibition of the RANKL-RANK Interaction.

The interaction between the receptor activator of nuclear factor-κB ligand (RANKL) and its receptor RANK is known to regulate osteoclastogenesis in bone remodelling and has become an important therapeutic target for the treatment of osteoporosis. Stephanine (SA), an isoquinoline aporphine-type alkaloid isolated from Stephania plants, possesses excellent anti-inflammatory effects and can be used for rheumatoid arthritis treatment. However, its specific role in osteoclastogenesis and osteoporosis remains unknown.

Pharmacokinetics and tissue distribution of key sesquiterpene glycosides in Dendrobium nobile analyzed by UHPLC-Q-Trap-MS/MS.

Dendrobium nobile (D. nobile), a traditional herb known for its immunomodulatory and neuroprotective properties, contains characteristic alkaloids and sesquiterpene glycosides. While alkaloids have been extensively studied, research on sesquiterpene glycosides remains limited.

Red Blood Cell Distribution Width/Hematocrit Ratio: A New Predictor of 28 Days All-Cause Mortality of AECOPD Patients in ICU.

Purpose: Elevated red blood cell distribution width (RDW) and decreased hematocrit (HCT) levels are associated with poor prognosis in chronic obstructive pulmonary disease (COPD) patients, but their significance in intensive care unit (ICU) patients with acute exacerbation of COPD (AECOPD) remains uncertain. The RDW/HCT ratio may offer a more comprehensive assessment compared to individual markers, potentially enhancing prognostic accuracy. Furthermore, the utility of RDW/HCT in improving traditional ICU scoring systems remains unexplored.

Drivers and Obstacles of Consumers' Continuous Participation Intention in Online Pre-Sales: Social Exchange Theory Perspective.

This study focuses on the factors influencing consumers' continuous participation willingness in online pre-sale activities. Based on perceived value and social exchange theory, it analyzes how perceived benefits (including practical benefits, hedonic benefits, and social benefits) and perceived costs (including search costs, waiting costs, and adjustment costs) affect consumer satisfaction and their continuous participation intention in online pre-sales. A total of 527 valid questionnaires were collected, and structural equation modeling was used for data analysis.

PhyloForge: Unifying Micro- and Macroevolution With Comprehensive Genomic Signals.

The dimensions of phylogenetic research have expanded to encompass the study of large-scale populations at the microevolutionary level and comparisons between different species or taxonomic units at the macroevolutionary level. Traditional phylogenetic tools often struggle to handle the diverse and complex data required for these different evolutionary scales. In response to this challenge, we introduce PhyloForge, a robust tool designed to seamlessly integrate the demands of both micro- and macroevolution, comprehensively utilising diverse phylogenomic signals, such as genes, SNPs, and structural variations, as well as mitochondrial and chloroplast genomes.

Antitumor Activity of a Bispecific Chimera Targeting EGFR and Met in Gefitinib-Resistant Non-Small Cell Lung Cancer.

Non-small cell lung cancers (NSCLC) frequently acquire resistance to tyrosine kinase inhibitors (TKI) due to epidermal growth factor receptor (EGFR) mutation or activation of the bypass pathway involving mesenchymal-epithelial transition factor (Met). To address this challenge, a bispecific nanobody-aptamer chimera is designed to target mutated EGFR and Met simultaneously to block their cross-talk in NSCLC. The EGFR-Met chimera is cost-effectively engineered using microbial transglutaminase and click chemistry strategies.

9-PAHSA ameliorates microvascular damage during cardiac ischaemia/reperfusion injury by promoting LKB1/AMPK/ULK1-mediated autophagy-dependent STING degradation.

Background: Considering that cardiac microvascular injury may play a more critical role than cardiomyocyte injury in the pathology of early ischaemia/reperfusion (I/R) injury, therapeutic strategies targeting the microvasculature are highly desirable. Palmitic acid-9-hydroxystearic acid (9-PAHSA) is a new class of bioactive anti-inflammatory lipids widely distributed in vegetables, fruits and medicinal plants, especially broccoli and apple. However, the pharmacological effects and underlying mechanisms of 9-PAHSA in protecting- against cardiac microvascular I/R injury have rarely been studied.