L-shaped association between lean body mass to visceral fat mass ratio with hyperuricemia: a cross-sectional study.

Background: Insufficient attention has been given to examining the correlation between body composition and hyperuricemia, leading to inconsistent findings. The primary objective of this research is to explore the association between lean body mass index (LMI), visceral fat mass index (VFMI), and hyperuricemia. A specific emphasis will be placed on assessing the link between the ratio of lean body mass to visceral fat mass (LMI/VFMI) and hyperuricemia.

Proteinase 3 depletion attenuates leukemia by promoting myeloid differentiation.

Hematopoietic stem and progenitor cells (HSPCs) that have impaired differentiation can transform into leukemic blasts. However, the mechanism that controls differentiation remains elusive. Here, we show that the genetic elimination of Proteinase 3 (PRTN3) in mice led to spontaneous myeloid differentiation.

Thrombectomy for delayed thromboembolism in a recurrent cerebral aneurysm previously treated with coiling: A case report.

Rationale: Giant intracranial aneurysms pose a significant threat due to high mortality rates upon rupture, prompting interventions such as neurosurgical clipping or endovascular coiling.

Patient Concerns: We present a rare case involving a 47-year-old female with a history of successfully treated ruptured giant intracranial aneurysms. Six months post-surgical clipping, she developed symptoms of acute ischemic stroke, prompting the decision for neurosurgical coiling and stent-assisted aneurysm coil embolization due to recurrent intracranial aneurysms.

Association between the homeostasis model assessment of insulin resistance and coronary artery calcification: a meta-analysis of observational studies.

Background: Insulin resistance (IR), a risk factor for cardiovascular diseases, has garnered significant attention in scientific research. Several studies have investigated the correlation between IR and coronary artery calcification (CAC), yielding varying results. In light of this, we conducted a systematic review to investigate the association between IR as evaluated by the homeostasis model assessment (HOMA-IR) and CAC.

Association between lean body mass to visceral fat mass ratio and bone mineral density in United States population: a cross-sectional study.

Background: Studies have explored the correlation between body composition and bone mineral density (BMD), but there has yet to be a consensus. Thus, the present study aims to comprehensively investigate the association between lean body mass, adipose tissue, and BMD.

Methods: We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) (2011-2018) with 11,227 subjects.

Anticipated correlation between lean body mass to visceral fat mass ratio and insulin resistance: NHANES 2011-2018.

Objective: The relationship between body composition and insulin resistance (IR) is controversial. This study aimed to thoroughly examine the correlation between adipose tissue, lean body mass, and IR as evaluated by the Homeostatic Model Assessment (HOMA-IR).

Methods: In this cross-sectional study, we utilized data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2018.

Association between the triglyceride-glucose index and arterial stiffness: A meta-analysis.

Background: Studies have shown a strong association between the triglyceride-glucose (TyG) index, a simple marker of insulin resistance, and various metabolic diseases. We performed a systematic review of the interaction between the TyG index and arterial stiffness.

Methods: Relevant observational studies assessing the association between the TyG index and arterial stiffness were thoroughly searched in PubMed, Embase, and Scopus, and a manual search of the preprint server was conducted.

Progress of Ecological Restoration Research Based on Bibliometric Analysis.

With the deterioration of the global/regional ecological environment, ecological restoration plays an important role in sustainable development. However, due to the differences in research methods, objectives, and perspectives, the research results are highly diverse. This makes it necessary to sort the publications related to ecological restoration, clarify the research status, grasp the research hotspots, and predict the future research trends.

A study on the neuroprotective effect of miR-206-3p on Alzheimer's disease mice by regulating brain-derived neurotrophic factor.

Background: Brain-derived neurotrophic factor (BDNF) is involved in the regulation of Alzheimer's disease (AD), but the mechanism is not clear. This study explores the possible mechanism of microRNA-206-3p (miR-206-3p) participating in the neuroprotective effect of AD mice by regulating BDNF.

Methods: 36 SPF grade C57 mice were randomly divided into normal group, model group and miR-206-3p mimics group (intraperitoneal injection of 3 mm miR-206-3p mimics) (n=12).

Supplement of Lipid Emulsion to Epinephrine Improves Resuscitation Outcomes of Asphyxia-Induced Cardiac Arrest in Aged Rats.

Objective: The goal of the study was to investigate the efficacy of lipid supplement to epinephrine-based therapy in resuscitation of asphyxia-induced cardiac arrest in aged rats.

Methods: The study included two parts: in experiment A, rats underwent asphyxial cardiac arrest and cardiopulmonary resuscitation, randomized to receive epinephrine and normal saline (control group, n=22), epinephrine and intralipid 20% (long-chain triglycerides (LCT) group, n=22) or epinephrine and lipovenoes 20% (LCT/medium-chain triglcerides (MCT) group, n=22). Return of spontaneous circulation, recurrence of asystole after resuscitation, hemodynamic metrics, arterial blood gas values, neurological assessment score and indexes of pulmonary transudation were recorded.

Preparation and evaluation of fluorescent poly(p-phenyleneethylene) covalently coated microspheres with reactive sites for bioconjugation.

Fluorescent microspheres with reactive sites for interacting with biomolecules are greatly demanded in flow cytometry based suspension array. Aiming to develop a new method for preparing fluorescent microspheres, two poly(p-phenyleneethylene) (PPE) conjugated polymers (CPs) with pedant carboxylic groups were synthesized via Sonogashira coupling and followed with hydrolysis of ester groups; then the conjugated polymers were immobilized onto monodispersed amino-modified porous poly(glycidylmethacrylate) (APGMA) microspheres via coupling reaction between carboxylic and amino groups to give APGMA-CP fluorescent microspheres. The fluorescent microspheres were found to have good photo- and thermal stability as well as negligible influence from rigorous washing.

Controlling factors of soil selenium distribution in a watershed in Se-enriched and longevity region of South China.

Selenium (Se) is an essential nutritional element for human beings. Many studies have been conducted on concentration and distribution patterns of soil Se in low Se, Se-enriched, and selenosis areas; however, soil Se has not been systematically studied in a watershed, especially in Se-enriched longevity region and karst area in South China. This study is carried out to explore the controlling factors of Se-enriched soils in Baishou river tributary watershed, where soils are Se-enriched, and local people have the phenomenon of longevity.

Perceived resource support for chronic illnesses among diabetics in north-western China.

A high level of social support can improve long-term diabetes self-management. Support from a single source has been evaluated. This study aims to analyze support from multiple and multilevel sources for diabetic patients by using the Chronic Illness Resources Survey (CIRS).

Facile preparation of polydiacetylene-based uniform porous fluorescent microspheres for potential immunoassay applications.

Fluorescent microspheres are prepared by attaching self-assembled polydiacetylene (PDA) vesicles with carboxyl side groups onto the substrate amino-modified poly(glycidylmethacrylate) (APGMA) microspheres. The characterization by SEM, confocal microscopy and flow cytometry demonstrated that the final resulting microspheres are highly uniform both in size (with a diameter of 5 μm) and in fluorescence emission (coefficient of variance < 3%). The Brunauer-Emmett-Teller (BET) surface area of these spheres is 114 m g.