Preparation and Properties of Nanoparticles, tRNA-Bivalent Metal Cation (Me) Complexes, and Prospects of Their Practical Use.

The patterns of formation of RNA nanoparticles (NPs) during thermal cycling of bacterial total tRNA in the presence of cations Ca, Mn, Ni, Zn, Co, and Cu were studied. The optimal conditions for the production of NPs were found, and it was revealed that their size depends on the ratio of the concentrations of Me and tRNA. The concentration of reagents for obtaining NPs of small size (from 5 to 100 nm) was selected.