Publications by authors named "Ya Jia"

The hydrogen abstraction reactions by small radicals from fuel molecules play an important role in the oxidation of fuels. However, experimental measurements and/or theoretical calculations of their rate constants under combustion conditions are very challenging due to their high reactivity. Machine learning offers a promising approach to predicting thermal rate constants.

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Energy absorption and consumption are essential for the activity of single neurons and neuronal networks. The synchronization mode transition and energy dependence in a delay-coupled FitzHugh-Nagumo (FHN) neuronal system driven by chaotic activity are investigated in this paper. With the change of chaotic current intensity, it was found that the synchronization mode of coupled neurons undergoes synchronous state, transition state, anti-phase state, alternating asynchronous and anti-phase state, and chaotic current-induced chaotic state.

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Article Synopsis
  • The study explores how the structure of neural networks affects working memory (WM) function, focusing on differences in microcircuits within a WM gradient network.
  • A spiking neural network model was developed that accurately mimics WM characteristics, showing that activity during memory delays is linked to the association cortex rather than the sensory cortex.
  • Key findings include the importance of small-world structures, balance between excitation and inhibition, and circuit cycles in sustaining WM activity, highlighting the need for further research on structural gradients in the brain.
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Behaviors and auditory physiological responses of some species of echolocating bats remain unaffected after exposure to intense noise, but information on the underlying mechanisms remains limited. Here, we studied whether the vocalization-induced middle ear muscle (MEM) contractions (MEM reflex) and auditory fovea contributed to the unimpaired auditory sensitivity of constant frequency-frequency modulation (CF-FM) bats after exposure to broad-band intense noise. The vocalizations of the CF-FM bat, Hipposideros pratti, were inhibited through anesthesia to eliminate the vocalization-induced MEM reflex.

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The functional neurons are basic building blocks of the nervous system and are responsible for transmitting information between different parts of the body. However, it is less known about the interaction between the neuron and the field. In this work, we propose a novel functional neuron by introducing a flux-controlled memristor into the FitzHugh-Nagumo neuron model, and the field effect is estimated by the memristor.

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Article Synopsis
  • * The research investigates this link in an adaptive neural network, showing that varying synaptic conductance leads to different collective behaviors such as phase synchronization and hierarchical states.
  • * Findings suggest a dynamic relationship where brain function emerges from its structural organization, with complex interactions affecting both structure and function simultaneously.
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Over the past decade, dynamic schemes have been proposed for the use of bistable systems in the design of logic devices. A bistable system in a noisy background can operate as a reliable logic gate in a moderate noise level, which is called a logical stochastic resonance (LSR). In this paper, we theoretically explore the emergence of LSR in general bistable systems and identify the dynamical mechanisms of LSR.

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The environment noise may disturb animal behavior and echolocation via three potential mechanisms: acoustic masking, reduced attention and noise avoidance. Compared with the mechanisms of reduced attention and noise avoidance, acoustic masking is thought to occur only when the signal and background noise overlap spectrally and temporally. In this study, we investigated the effects of spectrally non-overlapping noise on echolocation pulses and electrophysiological responses of a constant frequency-frequency modulation (CF-FM) bat, .

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The Lombard effect, referring to an involuntary rise in vocal intensity, is a widespread vertebrate mechanism that aims to maintain signal efficiency in response to ambient noise. Previous studies showed that the Lombard effect could be sufficiently implemented at subcortical levels and operated by continuously monitoring background noise, requiring some subcortical auditory sensitive neurons to have continuous responses to background noise. However, such neurons have not been well characterized.

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Introduction: The management of women with clinical early-stage cervical cancer and lymph node involvement detected intraoperatively is heterogeneous and controversial. This paper presents the protocol of a systematic review and meta-analysis regarding the management of this specific population of patients. This proposed study aims to answer the question: does completion of radical hysterectomy improve the oncological outcomes of women with clinical early-stage cervical cancer and intraoperatively detected nodal involvement?

Methods And Analysis: This protocol is drafted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines, and the proposed study will be conducted in accordance with the standard guidelines of 'Preferred Reporting Items for Systematic Reviews and Meta-Analyses' and 'Meta-analysis of Observational Studies in Epidemiology reporting guideline'.

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The influences of chaotic activity and time delay on the transmission of the sub-threshold signal (STS) in a single FitzHugh-Nagumo neuron and coupled neuronal networks are studied. It is found that a moderate chaotic activity level can enhance the system's detection and transmission of STS. This phenomenon is known as chaotic resonance (CR).

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Objective: The purpose of this study was to compare long-term survival outcomes of simple hysterectomy versus radical hysterectomy in stage IA2 cervical cancer.

Methods: A total of 440 patients who underwent simple hysterectomy (SH group) or radical hysterectomy (RH group) between 2014 and 2019 were included in this study. Overall survival (OS) and disease-free survival (DFS) were analyzed using the Kaplan-Meier method and compared by the Log rank test.

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Potassium ion and sodium ion channels play important roles in the propagation of action potentials along a myelinated axon. The random opening and closing of ion channels can cause the fluctuation of action potentials. In this paper, an improved Hodgkin-Huxley chain network model is proposed to study the effects of ion channel blocks, temperature, and ion channel noise on the propagation of action potentials along the myelinated axon.

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The bistable Rb-E2F gene regulatory network plays a central role in regulating cellular proliferation-quiescence transition. Based on Gillespie's chemical Langevin method, the stochastic bistable Rb-E2F gene's regulatory network with time delays is proposed. It is found that under the moderate intensity of internal noise, delay in the Cyclin E synthesis rate can greatly increase the average concentration value of E2F.

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Energy supply plays a key role in metabolism and signal transmission of biological individuals, neurons in a complex electromagnetic environment must be accompanied by the absorption and release of energy. In this paper, the discharge mode and the Hamiltonian energy are investigated within the Izhikevich neuronal model driven by external signals in the presence of electromagnetic induction. It is found that multiple electrical activity modes can be observed by changing external stimulus, and the Hamiltonian energy is more dependent on the discharge mode.

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Introduction: Uterine serous carcinoma accounts for only about 10% of all endometrial cancers but this subtype is the most common amongst non-endometrioid endometrium cancers and contributes to more than half of recurrence and deaths attributed to endometrial cancers. A more extensive surgical staging and adjuvant therapies for uterine serous carcinoma are recommended by many guidelines. However, guidelines vary on recommendations for the methods that should be used for omentum assessment in uterine serous carcinoma and the previously reported incidence of omental metastasis in uterine serous carcinoma had a wide range because of the heterogeneity among these studies.

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Background: Venous Thromboembolism (VTE) is a leading cause of morbidity and mortality in patients with ovarian malignancy. There is no meta-analysis available on this topic so far. The aim of our study was to quantitatively synthesize the data from studies with respect to the incidence and risk factors for postoperative VTE among cases with epithelial ovarian cancer (EOC).

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Objective: to investigate the birth experiences of women of advanced age having a second child in urban China after introduction of the universal two-child policy in 2016.

Design: data were collected using semi-structured in-depth interviews, and were processed and analysed using a qualitative phenomenological method.

Setting: obstetric department of a class 1, level 3 hospital in Henan Province, China.

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HIV is a virus that attacks the T cells. HIV may either actively replicate or become latent within host cells for years. Since HIV uses its own protein Tat to hijack the host CDK9-Cyclin complex for transcription, Tat is implicated in transcription-dependent HIV latency.

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Ionic channel blockage and multiple oscillatory signals play an important role in the dynamical response of pulse sequences. The effects of ionic channel blockage and ionic channel noise on the discharge behaviors are studied in Hodgkin-Huxley neuronal model with multiple oscillatory signals. It is found that bifurcation points of spontaneous discharge are altered through tuning the amplitude of multiple oscillatory signals, and the discharge cycle is changed by increasing the frequency of multiple oscillatory signals.

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Kinase proteins have been intensively investigated as drug targets for decades because of their crucial involvement in many biological pathways. Most kinase drugs target the catalytic ATP pocket, which is highly conserved across the kinome, and as such often leads to potential side effects. It is thus highly desirable to develop non-ATP-competitive drugs that inhibit kinase activity allosteric interactions.

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Background: The kinase pocket structural information is important for drug discovery targeting cancer or other diseases. Although some kinase sequence, structure or drug databases have been developed, the databases cannot be directly used in the kinase drug study. Therefore, a comprehensive database of human kinase protein pockets is urgently needed to be developed.

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Neuron shows distinct dependence of electrical activities on membrane patch temperature, and the mode transition of electrical activity is induced by the patch temperature through modulating the opening and closing rates of ion channels. In this paper, inspired by the physical effect of memristor, the potassium and sodium ion channels embedded in the membrane patch are updated by using memristor-based voltage gate variables, and an external stimulus is applied to detect the variety of mode selection in electrical activities under different patch temperatures. It is found that each ion channel can be regarded as a physical memristor, and the shape of pinched hysteresis loop of memristor is dependent on both input voltage and patch temperature.

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As the global population ages, searching for drugs and functional foods which can slow down the aging process has attracted a number of researchers. In this paper, the Lycium barbarum polysaccharides (LBP) extracted from Lycium barbarum was characterized and the effects of LBP on the aging and health of were studied. Results showed that LBP can prolong the lifespan, improve the abilities to withstand environmental stress, enhance reproductive potentials, and maintain muscle integrity of .

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