Publications by authors named "Ya Fei Li"

The pale grass blue, , is a small lycaenid butterfly widely distributed across Asia. Due to its exclusively diurnal lifestyle and conspicuous sexual dimorphism in wing coloration, vision has traditionally been regarded as the primary sensory system driving various behaviors. However, non-visual sensory systems related to sex-specific behavioral responses, such as antennae, have received far less attention.

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To elucidate the characteristics of VOCs chemical components during heavy pollution episodes, hourly online VOCs data derived from 11 heavy pollution events in Tianjin from 2019 to 2020 were employed. The positive matrix factorization (PMF) and conditional bivariate probability function (CBPF) were employed to analyze the sources of VOCs during heavy pollution episodes. The results indicated that the average VOCs volume fraction during these episodes was recorded at 35.

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Objective: To analyze the factors affecting overall survival (OS) of adult patients with core-binding factor acute myeloid leukemia (CBF-AML) and establish a prediction model.

Methods: A total of 216 newly diagnosed patients with CBF-AML in the First Affiliated Hospital of Zhengzhou University from May 2015 to July 2021 were retrospectively analyzed. The 216 CBF-AML patients were divided into the training and the validation cohort at 7∶3 ratio.

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A series of bis-naphthyl ferrocene derivatives were synthesized and characterized. Based on the results obtained from UV-visible absorption titration and ethidium bromide (EB) displacement experiments, it was observed that the synthesized compounds exhibited a strong binding ability to dsDNA. In comparison to the viscosity curve of EB, the tested compounds demonstrated a bisintercalation binding mode when interacting with CT-DNA.

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The effective and mild [4+1] annulation of ninhydrin-derived MBH carbonates with α,β-unsaturated ketones has been developed, providing a wide range of multisubstituted furans in high yields (up to 90%) with excellent β-regioselectivities. In contrast, the polysubstituted cyclopentenes bearing dispiro-bisindanedione motifs were obtained classical [3+2] annulations by employing ninhydrin-derived MBH carbonates with 2-arylidene-1,3-indandiones under the same catalytic conditions. Furthermore, the structures of two kinds of cycloadducts were straightforwardly confirmed through X-ray diffraction analysis.

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Sepsis-induced myocardial dysfunction (SIMD) has become one of the most lethal complications of sepsis, while the treatment was limited by a shortage of pertinent drugs. Epigallocatechin-3-gallate (EGCG) is the highest content of active substances in green tea, and its application in cardiovascular diseases has broad prospects. This study was conducted to test the hypothesis that EGCG was able to inhibit lipopolysaccharide (LPS) induced myocardial dysfunction and investigate the underlying molecular mechanisms.

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Bladder cancer (BCa) is heterogeneous in the tumour microenvironment (TME). However, the role of the TME in BCa in modulating the response to immunotherapy has not been fully explored. We therefore analysed fractions of immune cells using CIBERSORTx and clustered BCa into subtypes.

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Background: Tirofiban is a nonpeptide glycoprotein IIb/IIIa receptor antagonist used widely in patients subjected to percutaneous coronary intervention. While the usage of tirofiban sets an important clinical benefit, severe thrombocytopenia can occur with use of this agent.

Case Presentation: A 76-year-old Chinese man was admitted with 1-month history of sudden onset of chest tightness.

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The Escherichia coli-produced human papillomavirus (HPV) 16/18 bivalent vaccine (Cecolin) has received prequalification by the World Health Organization based on its high efficacy and good safety profile. We aimed to evaluate the immunogenicity and safety of the second-generation nonavalent HPV 6/11/16/18/31/33/45/52/58 vaccine (Cecolin 9) through the randomized, blinded phase 2 clinical trial. Eligible healthy women aged 18-45 years were randomly (1:1) allocated to receive three doses of 1.

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The change trend, relationship, and influencing factors of PM and O concentrations were analyzed by using a Kolmogorov-Zurbenko (KZ) filter coupled with stepwise multiple linear regression analysis and the spatiotemporal resolution monitoring data of PM and O and meteorological data observed in Tianjin from 2013 to 2020. The results showed that a significant decreasing trend of PM concentrations by 50.0% was observed from 2013 to 2020, whereas an increasing trend for O concentrations by 25.

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Background: A safe and highly efficacious ()-produced HPV 16/18 bivalent vaccine has been prequalified by the World Health Organization. Here, we conducted a single-center, open-label, dose-escalation phase 1 clinical trial to evaluate the safety and immunogenicity of the second-generation nonavalent HPV 6/11/16/18/31/33/45/52/58 vaccine.

Method: Twenty-four eligible volunteers aged 18-45 years were enrolled in January 2019 in Dongtai, China and received 0.

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Article Synopsis
  • Ambient air pollution significantly impacts health, leading to serious economic losses, particularly in Tianjin, China, where policies have notably improved air quality since 2013.
  • Health benefits were observed from reduced sulfur dioxide (SO) levels, preventing approximately 3,786 deaths in 2020 compared to 2013, while economic losses from air pollutants fluctuated between several billion and ten billion yuan.
  • Despite overall improvements, some heavy metals in particulate matter still pose respiratory cancer risks, and future health loss reduction will rely on integrated management strategies for particulate matter and ozone along with further health research.
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Background And Aims: Prospective cohorts are inconsistent regarding the association between dietary calcium intake and the risk of stroke. The aim was to perform a meta-analysis to determine whether an association exists between them in cohort studies.

Methods And Results: Relevant studies were identified by searching PubMed, EMBASE and Web of Science databases that published before December 2022.

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T-2 toxin is a mycotoxin with multiple toxic effects and has emerged as an important food pollutant. Microglia play a significant role in the toxicity of various neurotoxins. However, whether they participate in the neurotoxicity of T-2 toxin has not been reported.

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Unlabelled: ObjectiveTwo COVID-19 outbreaks occurred in Henan province in early 2022-one was a Delta variant outbreak and the other was an Omicron variant outbreak. COVID-19 vaccines used at the time of the outbreak were inactivated, 91.8%; protein subunit, 7.

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Clostridium butyricum (C. butyricum) can provide many benefits for animals' growth performance and gut health. In this study, we investigated the effects of on the growth performance, cecal microbiota, and plasma metabolome in Ira rabbits.

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Previous researches have reported the association between air pollution and various diseases. However, few researches have investigated whether air pollutants are associated with the economic loss resulting from patients' hospitalization, especially the economic loss of hospitalization due to acute cardiovascular events. The purpose of our research was to explore the association between the levels of carbon monoxide (CO), taken as an index of pollution, and the hospitalization costs of myocardial infarction (MI), and the potential effect modification by the ABO blood group.

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Evidence of the short-term effects of ambient sulfur dioxide (SO) exposure on the economic burden of ischemic stroke is limited. This study aimed to explore the association between short-term ambient SO exposure and hospitalization costs for ischemic stroke in Chongqing, the most populous city in China. The hospital-based study included 7271 ischemic stroke inpatients.

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Type 2 diabetes (T2DM) as a non-communicable disease imposes heavy disease burdens on society. Limited studies have been conducted to assess the effects of short-term air pollution exposure on T2DM, especially in Asian regions. Our research aimed to determine the association between short-term exposure to ambient nitrogen dioxide (NO) and outpatient visits for T2DM in Chongqing, the largest city in western China, based on the data collected from November 28, 2013 to December 31, 2019.

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Using a three-prefecture, two-variant COVID-19 outbreak in Henan province in January 2022, we evaluated the associations of primary and booster immunization with China-produced COVID-19 vaccines and COVID-19 pneumonia and SARS-CoV-2 viral load among persons infected by Delta or Omicron variant. We obtained demographic, clinical, vaccination, and multiple Ct values of infections ≥3 years of age. Vaccination status was either primary series ≥180 days prior to infection; primary series <180 days prior to infection, or booster dose recipient.

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Article Synopsis
  • A phase 1 clinical trial in Liuzhou, China enrolled 145 participants aged 18-55 to assess the safety and immune response of the HPV-6/11 vaccine, comparing three dosage levels (30, 60, and 90 μg) to a placebo.
  • The trial reported a total of 79 adverse events, primarily mild to moderate, with a higher incidence in the placebo group, while no serious adverse events were observed.
  • All participants developed specific antibodies by month 7, indicating that the vaccine is well tolerated and shows strong immune response, warranting further research with larger groups.
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Sleep disorders attract increasing concerns. However, the evidence of the association between ambient air pollution and sleep disorders is limited. Therefore, our aim was to determine the association between short-term air pollution exposure and outpatient visits for sleep disorders in Xi'an, the largest city in Northwest China.

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  • Research indicates that air pollution, specifically PM (particulate matter), is linked to inflammatory skin diseases, but the connection to acne vulgaris has been less explored.
  • A study in Chongqing, China analyzed 120,842 outpatient visits for acne between December 2013 and December 2019, using various models to assess PM exposure's impact on these visits.
  • Findings reveal that higher PM levels correlate with increased acne visits, particularly for individuals aged 25 and older, with a 10 μg/m increase resulting in a 1.71% uptick in visits, though no gender differences were observed.
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Article Synopsis
  • Adult mammals struggle with heart regeneration after injury, while neonatal mice can fully recover their heart tissue within a week.
  • Understanding factors that enhance the growth of heart cells (cardiomyocytes) is vital for creating effective cardiac regeneration treatments.
  • This study found that the protein MNK2 significantly boosts cardiomyocyte proliferation, both in lab settings and in living mice, by activating a pathway involving eIF4E and cyclin D1, highlighting MNK2 as a promising target for heart repair therapies.
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Ambient carbon monoxide (CO) is associated with bronchitis morbidity, but there is no evidence concerning its correlation with hospitalization costs for bronchitis patients. This study aimed to investigate the relationship between short-term ambient CO exposure and hospitalization costs for bronchitis patients in Chongqing, China. Baseline data for 3162 hospitalized bronchitis patients from November 2013 to December 2019 were collected.

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