The gene is responsible for intrinsic resistance to various drugs and virulence in by regulating cell division.

exhibits intrinsic resistance to most antibiotics, hence leading to infections that are difficult to treat. To address this issue, the identification of new molecular targets is essential for the development or repositioning of therapeutic agents. This study demonstrated that the -knockout strain, Mab, became significantly susceptible to a range of antibiotics, not only but also exhibited susceptibility to rifabutin, bedaquiline, and linezolid .

Identification and Functional Analysis of Strigolactone Pathway Genes Regulating Tillering Traits in Sugarcane.

Saccharum officinarum (S. officinarum) and Saccharum spontaneum (S. spontaneum) are two fundamental species of modern sugarcane cultivars, exhibiting divergent tillering patterns crucial for sugarcane architecture and yield.

High-Entropy and Na-Rich-Designed High-Energy-Density NaV(PO)/C Cathode.

The NaV(PO) (NVP) cathode holds the merit of a stable 3D NASICON structure for ultrafast Na diffusion, yet it is still confronted with poor electronic conductivity (10 S cm) and insufficient energy density (∼370 W h kg). Herein, a series of high-entropy-doped NaVZn(GaCrAlIn)(PO) ( = 0, 0.2, 0.

-CoFeO/TiCT/BNC Hybrid Aerogels with Modulation Impedance Matching for Electromagnetic Wave Absorption and Health Monitoring.

Given the limitations of single-function electromagnetic wave-absorbing materials (EWAMs) in meeting the evolving demands of complex usage scenarios, there is a growing need for structure-function integrated composites that offer a combination of microwave absorption, human monitoring, and thermal insulation. This study successfully synthesized two-dimensional (2D) TiCT MXene via selective etching of Al from the TiAlC MAX phase. By introducing MXene into a composite of hydroxylated CoFeO nanoparticles (-CFO NPs) and bacterial nanocellulose (BNC) to modulate the electromagnetic performance of the EWAMs.

Hematoma surface irregularity predicts postoperative rebleeding and poor drainage in patients with spontaneous intracerebral hemorrhage following minimally invasive surgery: a retrospective cohort study at a high-volume stroke center.

Background: The surface regularity index (SRI) reflects hematoma surface regularity in patients with intracerebral hemorrhage (ICH). Studies had reported an association between hematoma surface irregularity and hematoma expansion (HE). However, research on the correlation between the SRI and clinical outcomes in ICH patients following minimally invasive surgery (MIS) is limited.

Deep learning-based reconstruction: a reliability assessment in preoperative magnetic resonance imaging for primary rectal cancer.

Background: Deep learning has developed rapidly, and deep learning reconstruction (DLR) methods in magnetic resonance imaging (MRI) are gaining attention for their potential to improve efficacy in clinical work. The preoperative MRI assessment of rectal cancer is crucial for patient management, but the imaging quality is currently limited by a number of factors. DLR could be applied to the preoperative MRI assessment of primary rectal cancer, but research about its specific reliability is limited.

Quantitative assessment of pulmonary blood flow redistribution in the classification of group 1 and group 4 pulmonary hypertension.

Background: All patients with pulmonary hypertension (PH), without left heart disease or lung diseases, need further distinguishing between pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). This study aimed to investigate the value of quantitative assessment of pulmonary blood flow redistribution in further classification.

Methods: Forty-six patients who underwent echocardiography and computed tomography pulmonary angiography at The First Affiliated Hospital of Xi'an Jiaotong University were included in this cross-sectional study, and all patients were categorized into a non-PH group (18 cases), a PAH group (12 cases), and a CTEPH group (16 cases).

Alterations in the white matter fiber tracts of preschool-aged children with autism spectrum disorder: an automated fiber quantification study.

Background: Little is known about the precise impaired patterns of white matter (WM) fiber tracts in preschool-aged children with autism spectrum disorder (ASD). Thus, we used diffusion tensor imaging (DTI)-based automated fiber quantification (AFQ) to explore the changes in WM fiber tracts in preschool-aged children with ASD and its correlation with the severity of clinical manifestations.

Methods: A total of 43 pediatric ASD and 42 age- and sex-matched typical developing children were examined with DTI.

Comparing core needle biopsy and surgical excision in breast cancer diagnosis: implications for clinical practice from a retrospective cohort study.

Background: Preoperative ultrasound-guided core needle biopsy (CNB) is currently the standard procedure for managing breast illnesses. However, the differences in outcomes between CNB and surgical excision (SE) have not been thoroughly assessed. This study aimed to explore the disparities in pathological outcomes between these two procedures, using a large sample dataset.

Case report: A novel nonsense mutation in the gene causes nonsyndromic hearing loss in a China family.

The gene is located on chromosome 5q13.2 and is associated with autosomal recessive nonsyndromic hearing loss (OMIM: # 610572). In this study, we identified and reported a novel nonsense mutation in c.

SGLT2-Inhibition in Patients With Alport Syndrome.

Introduction: Large-scale trials showed positive outcomes of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in adults with chronic kidney disease (CKD). Whether the use of SGLT2i is safe and effective in patients with the common hereditary CKD Alport syndrome (AS) has not yet been investigated specifically in larger cohorts.

Methods: This observational, multicenter, international study (NCT02378805) assessed 112 patients with AS after start of SGLT2i.

Rising challenges in periprosthetic joint infections: a focus on rare pathogens and their clinical implications.

Objectives: The study aimed to evaluate differences in clinical characteristics and treatment outcomes of periprosthetic joint infection (PJI) attributed to rare versus common pathogens.

Methods: Data on PJI patients who underwent hip or knee arthroplasty at our center from April 2013 to December 2022 were retrospectively collected. Among the 219 enrolled patients, we compared 32 cases of PJI caused by rare pathogens with 187 controls of PJI caused by common pathogens, analyzing demographic information, clinical characteristics, and treatment outcomes.

Corrigendum: A rapid and visual detection assay for Senecavirus A based on recombinase-aided amplification and lateral flow dipstick.

[This corrects the article DOI: 10.3389/fcimb.2024.

Enhanced sclerotherapy for vascular malformations: A dual-mechanism approach using in-situ forming PATDs gel.

Vascular malformations are common vascular lesions in infants and seriously affect their health and quality of life. Vascular sclerotherapy is an effective treatment for vascular malformations. However, current sclerosants have difficulty achieving both high efficiency and low toxicity, and their dosing forms make it difficult to achieve long-term retention in the affected blood vessels.

Nomogram for Predicting in-Hospital Severe Complications in Patients with Acute Myocardial Infarction Admitted in Emergency Department.

Background: There is lack of predictive models for the risk of severe complications during hospitalization in patients with acute myocardial infarction (AMI). In this study, we aimed to create a nomogram to forecast the likelihood of in-hospital severe complications in AMI.

Methods: From August 2020 to January 2023, 1024 patients with AMI including the modeling group (n=717) and the validation group (n=307) admitted in Changsha Central Hospital's emergency department.

Treatment of superficial corneal opacities with corneal stromal lenticule obtained through SMILE surgery.

Aim: To evaluate the clinical efficacy and feasibility of superficial corneal opacities treated by excimer laser phototherapeutic keratectomy (PTK) combined with small incision lenticule extraction (SMILE)-derived corneal stromal lenticule transplantation.

Methods: A retrospective interventional case series of nine patients aged 12-59y with superficial corneal opacity caused by different pathologies who underwent standardized PTK combined with SMILE-derived corneal stromal lenticule transplantation was examined. Lenticule patches were fixed with fibrin glue.

Effect of Perfectionism on Interpersonal Sensitivity Among Nursing Students: The Mediating Role of Coping Style and Subjective Well-Being.

Aim: To explore the connection between perfectionism and interpersonal sensitivity among nursing students and to examine the intermediary effects of coping style and subjective well-being within this association.

Methods: Utilizing a cross-sectional approach, this study assessed 682 nursing students at two Henan Province universities in China, employing the Multidimensional Perfectionism Scale, Interpersonal Sensitivity Questionnaire, Coping Style Scale, and Subjective Well-being Scale. The data were subjected to descriptive statistics, Pearson correlation, and regression analysis with a macro process model.

Siglec15 in blood system diseases: from bench to bedside.

Inhibiting the PD-1/PD-L1 pathway using immunomodulators has demonstrated promising outcomes in clinics. Immunomodulators can effectively target immune checkpoints with a strong preference for the tumor microenvironment (TME). Besides, immunomodulators specifically target the recently discovered inhibitory immune checkpoint, sialic acid-binding immunoglobulin-like lectin (Siglec-15).

A diagnostic index for predicting heart rate variability decline and prognostic value in newly diagnosed non-small cell lung cancer patients.

Background: Heart rate variability (HRV) is an important marker of autonomic nervous system function and cardiovascular health. Holter monitoring is a crucial method for evaluating HRV, but the procedure and result analysis are relatively complex. This study aims to develop a simplified diagnostic index for predicting HRV decline in newly diagnosed non-small cell lung cancer (NSCLC) patients and evaluate its prognostic value.

Association between osteoarthritis-related serum biochemical markers over 10-13 years and knee symptoms in middle-aged adults.

Objectives: To describe the associations between OA-related biochemical markers and knee symptoms in middle-aged adults followed up over 10-13 years.

Methods: Blood samples were collected during the Childhood Determinants of Adult Health (CDAH)-1 study (year: 2004-06) and 10-13 year follow-up at CDAH-3. Serum samples from baseline (n=156) and follow-up (n=167) were analyzed for three OA-related biomarkers [cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-3, and hyaluronan (HA)] using non-isotopic enzyme-linked immunosorbent assay (ELISA).

Proteomic analysis for busulfan-induced spermatogenesis disorder.

Background: Busulfan is the most commonly used drug for the treatment of chronic myelogenous leukemia and pretreatment for hematopoietic stem cell transplantation, which can damage the reproductive and immune system. However, little is known about the protein expression profiling in busulfan treated testis.

Methods: This research studies the proteomics for busulfan-induced spermatogenesis disorder.

[Establishment of a nomogram prediction model for 28-day mortality of septic shock patients based on routine laboratory data mining].

Objective: To construct a nomogram prediction model for 28-day mortality in septic shock patients based on routine laboratory data mining and verify its predictive value.

Methods: The clinical data of patients with septic shock admitted to Anhui Medical University Affiliated Fuyang Hospital from January 2018 to November 2023 were retrospectively analyzed. The patients were randomly divided into training set and validation set according to the ratio of 8 : 2.

Development and validation of attitudes toward inclusive education scale among Chinese normal universities students' attitudes.

Purpose: Inclusive education plays a crucial role in integrating students with special educational needs (SEN) into mainstream schools, where the attitudes of pre-service teachers are pivotal. Despite recognizing the significance of these attitudes, there is currently a gap in understanding the perspectives of students attending normal universities in China regarding inclusive education practices. This study aims to bridge this gap by creating the Chinese version of the Normal Universities Students' Attitudes Toward Inclusive Education Scale (NUSATIES) and examining its psychometric properties.

Preoperative assessment of tertiary lymphoid structures in stage I lung adenocarcinoma using CT radiomics: a multicenter retrospective cohort study.

Objective: To develop a multimodal predictive model, Radiomics Integrated TLSs System (RAITS), based on preoperative CT radiomic features for the identification of TLSs in stage I lung adenocarcinoma patients and to evaluate its potential in prognosis stratification and guiding personalized treatment.

Methods: The most recent preoperative chest CT thin-slice scans and postoperative hematoxylin and eosin-stained pathology sections of patients diagnosed with stage I LUAD were retrospectively collected. Tumor segmentation was achieved using an automatic virtual adversarial training segmentation algorithm based on a three-dimensional U-shape convolutional neural network (3D U-Net).

Identification of Brucella RS15060 as a novel type IV secretion system effector associated with bacterial virulence.

Brucella is an intracellular parasitic pathogen that causes the worldwide zoonotic disease brucellosis. The type IV secretion system (T4SS) is utilized to secrete various effectors to help Brucella form Brucella-containing vacuoles within the cell and accomplish intracellular trafficking and replication. Brucella has fewer recognized effector proteins than other intracellular parasites in the Proteobacteria, indicating that Brucella may contain a large number of unidentified effector proteins.