A Glutamate Receptor-Like Gene AtGLR25 With Its Unusual Splice Variant Has a Role in Mediating Glutamate-Elicited Changes in Arabidopsis Root Architecture.

The occurrence of external L-glutamate at the Arabidopsis root tip triggers major changes in root architecture, but the mechanism of -L-Glu sensing is unknown. Members of the family of GLUTAMATE RECEPTOR-LIKE (GLR) proteins are known to act as amino acid-gated Ca-permeable channels and to have signalling roles in diverse plant processes. To investigate the possible role of GLRs in the root architectural response to L-Glu, we screened a collection of mutants with T-DNA insertions in each of the 20 AtGLR genes.

Vodobatinib overcomes cancer multidrug resistance by attenuating the drug efflux function of ABCB1 and ABCG2.

Multidrug resistance (MDR) remains a significant obstacle in cancer treatment, primarily attributable to the overexpression of ATP-binding cassette (ABC) transporters such as ABCB1 and ABCG2 within cancer cells. These transporters actively diminish the effectiveness of cytotoxic drugs by facilitating ATP hydrolysis-dependent drug efflux, thereby reducing intracellular drug accumulation. Given the absence of approved treatments for multidrug-resistant cancers and the established benefits of combining tyrosine kinase inhibitors (TKIs) with conventional anticancer drugs, we investigate the potential of vodobatinib, a potent c-Abl TKI presently in clinical trials, to restore sensitivity to chemotherapeutic agents in multidrug-resistant cancer cells overexpressing ABCB1 and ABCG2.

Distinct Gut Microbiota Profiles in Normal Weight Obesity and Their Association With Cardiometabolic Diseases: Results From Two Independent Cohort Studies.

Background: Normal weight obesity (NWO) is characterized by excess body fat in individuals with normal body mass index (BMI). This study aimed to investigate gut microbiota alterations in NWO and their potential associations with cardiometabolic diseases (CMD) risk in two independent cohorts.

Methods: Our NWO-CMD mortality analysis included 168 099 adults with normal BMI from two large open-access databases, while our NWO-gut microbiota study involved 5467 adults with normal BMI from two independent cohorts: the WELL-China cohort and the Lanxi cohort.

Prevalence of mental disorders and their associations with age at diagnosis and time since diagnosis of nasopharyngeal cancer.

Background: Despite advancements in cancer treatment, understanding the long-term mental health implications for nasopharyngeal carcinoma (NPC) survivors remains an underexplored area. This study aims to examine the prevalence of mental disorders and their correlations with age at diagnosis and time since diagnosis among NPC survivors.

Methods: A total of 1872 NPC patients were surveyed from September 2020 to June 2021 in this cross-sectional survey.

In vitro antimicrobial and cytotoxic potential against colorectal cancer cell lines using ethanolic leaf extract of Sansevieria trifasciata (Agavaceae).

Background: Sansevieria trifasciata, common name, mother-in-law's tongue, is a member of the Agavaceae family. We undertook this study to evaluate the cytotoxicity of S. trifasciata leaf extract against two cancer cell lines as well as its antibacterial activities against six bacterial strains.

Characteristics of hydrocolloids and their effects on intestine PPAR signaling and liver lipid metabolism in : A multiomics analysis.

This study evaluated the effects of hydrocolloids on Nile tilapia () using an advanced multiomics approach (transcriptome and proteome) linked with genomic isoform structure to elucidate the biofunctions of hydrocolloids. The results showed that hydrocolloids did not affect growth, as indicated by the nonsignificant differences in growth and blood biochemical indicators. Regarding the response, both intestine and liver tissues were assessed.

Revealing the Effect of Crystalline Self-Assembled Monolayer in Biomimetic Photosynapse with Ultraviolet Light Protection Capability.

The research on photonic synapses holds immense promise for various applications, such as robotics and artificial intelligence. Pursuing lightweight, miniaturized, and low-energy consumption designs is crucial for enhancing efficiency and adaptability in evolving technological environments. To achieve this goal, this work designs a series of conjugated self-assembled molecules with photoactive pyrene, benzo-naphthol-thiophene (BNT), perylene, and benzothieno-benzothiophene cores to develop ultrathin (<3 nm) charge-trapping self-assembled monolayers (SAMs).

Hyalinizing clear cell carcinoma of the lung: a case report and literature review.

Background: Primary pulmonary hyalinizing clear cell carcinoma (HCCC) is an exceedingly rare tumor with unique clinicopathological features, posing major diagnostic challenges.

Case Presentation: We present a case of a 74-year-old woman with a lung nodule incidentally detected in the right middle lobe (RML) through F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) imaging. Through comprehensive evaluations by thoracic surgeons, she underwent video-assisted thoracic surgery of RML lobectomy to excise the lung nodule.

Antibiotic use in a co-infection of respiratory syncytial virus and pathogenic bacteria in children in a resource-limited setting in northeast Peninsular Malaysia.

To investigate co-infection of bacterial isolates associated with respiratory syncytial virus (RSV) in children aged less than two years who were admitted to hospital with confirmed lower respiratory tract infection (LRTI) in Kelantan, Malaysia. The demographic data, clinical history, case management, haematological as well as infectious parameters (white blood cell differential and count, plus C-reactive protein, CRP) of the patients were systematically recorded. Less than one-third of cases were RSV-positive (21.

Cobalt nanoclusters Deposit on Nitrogen-Doped graphene Sheets as bifunctional electrocatalysts for high performance lithium - Oxygen batteries.

Rechargeable lithium-oxygen (Li-O) batteries are being considered as the next-generation energy storage systems due to their higher theoretical energy density. However, the practical application of Li-O batteries is hindered by slow kinetics and the formation of side products during the oxygen reduction and evolution reactions on the cathode. These reactions lead to high overpotentials during charging and discharging.

Toxicity, mutagenicity, and source identification of polycyclic aromatic hydrocarbons in ambient atmosphere and flue gas.

This study aimed to assess the characteristics of particulate matter (PM) and polycyclic aromatic hydrocarbons (PAHs) from various stationary and mobile emission sources in Taiwan, with a focus on source apportionment and associated health risks. The northern power plant, equipped with bag filters operating at 150 °C, had significantly lower FPM and CPM levels (0.44 and 0.

Neurocognitive effects of proanthocyanidin in Alzheimer's disease: a systematic review of preclinical evidence.

Cognitive disorders and dementia largely influence individual independence and orientation. Based on the Alzheimer's Disease International (ADI) estimation, approximately 75% of individuals with dementia are undiagnosed. In fact, in some low- and middle-income countries, the percentage is as high as 90%.

Comparative Effects of Crude Extracts and Bioactive Compounds from and on Nonspecific Immune Responses and Antibacterial Activity Against sp. in Coculture with Lactic Acid Bacteria in Hybrid Grouper ( ♀ × ♂).

This study investigated the effect of substances on nonspecific immune responses of head kidney leukocytes, the antimicrobial activity against sp., as well as the time-kill of sp. by combining the substances with lactic acid bacteria (LAB) and sp.

The colony-stimulating factor-1 receptor inhibitor edicotinib counteracts multidrug resistance in cancer cells by inhibiting ABCG2-mediated drug efflux.

Chemotherapy treatment faces a major obstacle with the emergence of multidrug resistance (MDR), often attributed to the elevated expression of ATP-binding cassette (ABC) transporters such as ABCG2 and ABCB1 in cancer cells. These transporters hinder the efficacy of cytotoxic drugs via ATP hydrolysis-dependent efflux, leading to diminished intracellular drug levels. The scarcity of approved treatments for multidrug resistant cancers necessitates exploration of alternative strategies, including drug repositioning of molecular targeted agents to counteract ABCG2-mediated MDR in multidrug-resistant cancer cells.

Effects of the types and ages of vegetation restoration on land surface roughness in the Eastern Hobq Desert, Northern China.

Vegetation restoration has an important remodelling effect on near-surface characteristics, and consequent changes in land surface roughness (LSR) are key influences on soil wind erosion processes. However, the effects of vegetation restoration types and ages on LSR and the underlying mechanisms are not fully understood. In this study, the sand-fixing vegetation restoration area of the Hobq Desert was examined in comparison to a bare sand control area.

Cataloguing the postnatal small intestinal transcriptome during the first postnatal month.

In the first postnatal month, the developing mouse intestine shifts from an immature to a mature intestine that will sustain the organism throughout the lifespan. Here, we surveyed the mouse intestine in C57Bl/6 mice by RNA-Seq to evaluate the changes in gene expression over time from the day of birth through 1 month of age in both the duodenum and ileum. We analyzed gene expression for changes in gene families that correlated with the periods of NEC susceptibility or resistance.

Establishment of appropriate conditions for the efficient determination of multiple mycotoxins in tea samples and assessment of their drinking risks.

Conditions were determined for rapid, convenient, and efficient determination of 16 common mycotoxins in tea samples. Mycotoxins in tea leaves and tea infusion samples were extracted using solid-liquid extraction/liquid-liquid extraction combined with ultrasonic-assisted extraction. The extraction solvent was 2-butanone/ethyl acetate (9/1 v/v) with 0.

Synthesis and dengue inhibition potential of new uridine derivatives: The DENV 2 inhibitors.

Dengue is an important arboviral infection worldwide for which presently there is no specific medicine. Evidence suggests there are four serotypes of dengue virus (DENV1-4), of which DENV 2 is considered to cause the most sever dengue. Therefore, this study was aimed to develop the new uridine derivatives (NUDs) against dengue virus (DENV 2).

Decoding the molecular symphony: interactions between the mA and p53 signaling pathways in cancer.

The p53 tumor suppressor gene governs a multitude of complex cellular processes that are essential for anti-cancer function and whose dysregulation leads to aberrant gene transcription, activation of oncogenic signaling and cancer development. Although mutations can occur at any point in the genetic sequence, missense mutations comprise the majority of observed p53 mutations in cancers regardless of whether the mutation is germline or somatic. One biological process involved in both mutant and wild-type p53 signaling is the -methyladenosine (mA) epitranscriptomic network, a type of post-transcriptional modification involved in over half of all eukaryotic mRNAs.