Anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in 588 patients with oral lichen planus.

Background/purpose: Our previous study found that 21.9 %, 13.6 %, 7.

Psychotropic Polypharmacy in Dementia: A Retrospective Analysis for People with Neuropsychiatric Symptoms Referred to an Australian Dementia Support Service.

Background And Objectives: Despite their limited benefits and serious adverse effects, psychotropics remain frequently prescribed for neuropsychiatric symptoms (NPS) of dementia. Psychotropic polypharmacy, the use of two or more concomitant psychotropic medications, is therefore not recommended for people with dementia. The objectives of this study were to investigate the prevalence of psychotropic polypharmacy in Australians living with dementia whose caregivers sought external NPS support from Dementia Support Australia (DSA; the national provider of NPS support) and the association of psychotropic polypharmacy with their demographics and NPS characteristics.

Delving into the world of webCHAT - an e-mental health support service for distressed youths in Singapore.

Background: Young people face high rates of mental health issues, yet many do not seek professional help. In 2017, CHAT launched webCHAT - a free, anonymous, one-on-one synchronous web-based text service managed by case managers (CMs) to support young people aged 16 to 30 who may be hesitant about engaging in face-to-face mental health services.

Objective: This study aimed to explore the perspectives and experiences of users who accessed webCHAT for mental health support in Singapore.

Efficacy of solution-focused brief therapy versus case management for psychological distress in adolescents and young adults in a community-based youth mental health service in Singapore: protocol for a randomised controlled trial.

Introduction: There are insufficient scalable, evidence-based treatments to meet increasing mental health needs of young people. Offering interim, brief interventions for young persons with psychological distress can improve access to care and mitigate adverse effects of long waiting times. This study tests the efficacy of solution-focused brief therapy (SFBT), a strength-based, goal-directed intervention, in adolescents and young adults at a community-based youth mental health service in Singapore.

Unique Applications of -Hydrogen Matrix Isolation to Spectroscopy and Astrochemistry.

Cryogenic solid -hydrogen (-H) exhibits pronounced quantum effects, enabling unique experiments that are typically not possible in noble-gas matrices. The diminished cage effect facilitates the production of free radicals via photolysis or photoinduced reactions. Electron bombardment during deposition readily produces protonated and hydrogenated species, such as polycyclic aromatic hydrocarbons, that are important in astrochemistry.

Rate Coefficient and Branching Ratio for the Formation of Criegee Intermediate S-/A-CHCHOO from CHCHI + O and the Self-Reaction of S-/A-CHCHOO Determined with Simultaneous IR/UV Probes.

A flow reactor coupled with a light-emitting diode at 286 nm, an infrared quantum-cascade laser near 11 μm, and an ultraviolet laser at 335 nm was implemented to probe the precursor CHCHI, -CHCHOO, and /-CHCHOO, respectively, in the reaction of CHCHI + O. The branching between - and -CHCHOO was determined to be ≈80:20 from two methods. The concentration temporal profiles of -CHCHOO, derived on comparison of infrared and ultraviolet profiles, yielded the rate coefficient for the self-reaction of -CHCHOO, = (6 ± 2) × 10 cm molecule s, ∼4 times the corresponding value, = (1.

Electronic Spectroscopy of Ovalene: Reassignment of the ()- () Transition.

As part of our experiments to characterize solid -hydrogen (-H) as a matrix host for electronic spectroscopy with potential applications in the ongoing quest for the carriers of the diffuse interstellar bands (DIB), we studied dispersed fluorescence and fluorescence excitation spectra of ovalene (CH), a planar polycyclic aromatic hydrocarbon (PAH) of symmetry. Although generally in good agreement with previously reported data for jet-cooled CH, our results, in conjunction with quantum-chemical calculations, indicate that the observed spectral progressions are associated with the ()-() electronic transition instead of the originally assigned - transition for CH in a supersonic jet, and that the previously reported origin band was misassigned and should be located at ∼21050 cm. The reassignment is further supported by the comparably long fluorescence lifetime of ∼1.

Infrared Spectrum of the Adduct 2-Chloro-2-hydroperoxybut-3-ene [(CH)CCl(CH)OOH] of the Reaction between the Criegee Intermediate Methyl Vinyl Ketone Oxide [CHC(CH)OO] and HCl.

Methyl vinyl ketone oxide (MVKO, CHC(CH)OO) is an important Criegee intermediate produced from ozonolysis of isoprene, which is the most abundant nonmethane hydrocarbon emitted into the atmosphere. Reactions between Criegee intermediate and hydrogen chloride (HCl) are important because of their large rate coefficients. In this work, we photolyzed a mixture of ()-(CHI)HC═C(CH)I/HCl/O at 248 nm to produce MVKO to carry out the reaction MVKO + HCl and recorded infrared spectra of transient species with a step-scan Fourier-transform infrared absorption spectrometer.

Co-exposure to different bacterial species' lipopolysaccharides with the NASH diet exacerbates NASH and liver fibrosis progression in mice.

Background And Aim: With the obesity epidemic, nonalcoholic fatty liver disease (NAFLD) has become a public health concern, but its progression mechanism remains unclear. Experimental models mimicking human NAFLD/steatohepatitis (NASH) are crucial. This study simulates gut microbiota imbalance effects on NASH and liver fibrosis.

Escape rooms in pharmacy education: More than just a game.

Unlabelled: An educational escape room is a form of game-based learning that has been shown to improve students' learning experience. A cardiovascular escape room was designed to promote the development of transversal skills and help students retain learned content knowledge in an integrated pharmacology and therapeutic unit in a Pharmacy course.

Objective: This study aims to design, pilot, and evaluate the students' self-perceived transversal skills, learning experience and knowledge acquisition from a cardiovascular educational escape room.

Accelerated differentiation of neo-W nuclear-encoded mitochondrial genes between two climate-associated bird lineages signals potential co-evolution with mitogenomes.

There is considerable evidence for mitochondrial-nuclear co-adaptation as a key evolutionary driver. Hypotheses regarding the roles of sex-linkage have emphasized Z-linked nuclear genes with mitochondrial function (N-mt genes), whereas it remains contentious whether the perfect co-inheritance of W genes with mitogenomes could hinder or facilitate co-adaptation. Young (neo-) sex chromosomes that possess relatively many N-mt genes compared to older chromosomes provide unprecedented hypothesis-testing opportunities.

Identification of HOCHC(O)H, HOCHCO, and HOCHCHO Intermediates in the Reaction of H + Glycolaldehyde in Solid -Hydrogen and Its Implication to the Interstellar Formation of Complex Sugars.

Glycolaldehyde [HOCHC(O)H, GA], the primitive sugar-like molecule detected in the interstellar medium (ISM), is a potential precursor for the synthesis of complex sugars. Despite its importance, the mechanism governing the formation of these higher-order sugars from GA under interstellar circumstances remains elusive. Radical intermediates HOCHCHO (), HOCHCHOH (), HOCHCO (), HOCHC(O)H (), and OCHC(O)H () derived from GA could be potential precursors for the formation of glyceraldehyde (aldose sugar), dihydroxyacetone (ketose sugar), and ethylene glycol (sugar alcohol) in dark regions of ISM.

Efficacy of ferric carboxymaltose or darbepoetin alfa for chemotherapy-induced anemia in patients with esophagogastric or pancreaticobiliary cancer: a retrospective comparative study.

Background: Esophagogastric and pancreaticobiliary cancers are associated with chronic blood loss, poor nutrition, and surgical interventions that interfere with iron absorption. Patients with these cancers often have a higher incidence of chemotherapy-induced anemia (CIA) than patients with other malignancies.

Objectives: To investigate the efficacy of intravenous iron or erythropoietin-stimulating agents (ESA) for CIA treatment in patients with esophagogastric or pancreaticobiliary cancer.

Fluorescence Excitation and Dispersed Fluorescence Spectra of the First Electronic Excited (S) State of -Hexabenzocoronene (CH) Isolated in Solid -Hydrogen.

Large polycyclic aromatic hydrocarbons (PAH) and their cationic, hydrogenated, and protonated derivatives have long been considered as promising candidates for the carriers of the diffuse interstellar bands. -Hexabenzocoronene (-HBC, CH) is a large, compact PAH, and, to the best of our knowledge, the largest centrosymmetric all-benzenoid PAH for which electronic spectroscopy data has been published. In this work, we present the dispersed fluorescence and fluorescence excitation spectra of the first electronic excited (S) state of -HBC isolated in solid -H and provide the first detailed vibronic analysis of observed features.

Does obesity and varying body mass index affect the clinical outcomes and safety of biportal endoscopic lumbar decompression? A comparative cohort study.

Background: Endoscopic spine surgery has recently grown in popularity due to the potential benefits of reduced pain and faster recovery time as compared to open surgery. Biportal spinal endoscopy has been successfully applied to lumbar disc herniations and lumbar spinal stenosis. Obesity is associated with increased risk of complications in spine surgery.

Elevated Serum Alkaline Phosphatase is an Independent Predictor of Complications After Lumbar Spinal Fusion.

Background: Alkaline phosphatase (ALP) is an enzyme which has been proven useful as a biomarker for bone turnover and inflammation. We hypothesized that high serum ALP levels are associated with increased complication rates following lumbar spinal fusion.

Methods: Lumbar spinal fusion procedures from 2005 to 2019 were queried from the National Surgical Quality Improvement Program (NSQIP) database.